Stress-Induced Senescence of Dermal Papilla Cells Restored by Synthesized Ceramide

September 2017 in “ Journal of Investigative Dermatology ”

J. Kim, Jee Hye Oh, Kwan Ho Jeong, Ji Hee Jung, Young Jun Woo, Ki Min Sohn, Hoon Kang

ceramide dermal papilla cells ERK/Akt pathway Wnt/β-catenin pathway Wnt5a β-catenin Wnt10b hair follicles hair senescence

TLDR Ceramide may help delay hair aging by restoring stressed hair cells.

The study investigated the effects of ceramide on stress-induced senescence in dermal papilla cells (DPCs), focusing on growth factors like ERK/Akt and Wnt/β-catenin pathways. It was found that ceramide decreased Akt phosphorylation and significantly increased ERK phosphorylation in H2O2-treated DPCs. Additionally, ceramide alone increased Wnt5a and β-catenin mRNA levels and upregulated Wnt10b expression in stressed DPCs. These findings suggested that ceramide could play a role in maintaining hair follicles in aging or stress conditions, potentially serving as an adjunctive material to delay hair senescence.

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