The Role of PGC-1α in Aging Skin Barrier Function

    July 2024 in “ Cells ”
    Yonghong Luo, Wendy B. Bollag
    Studysummary In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. The Skin and Inflamm-Aging Biology · 2023
    2. PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation iScience · 2023
    3. Pgc-1α Controls Epidermal Stem Cell Fate And Skin Repair By Sustaining NAD+ Homeostasis During Aging Molecular Metabolism · 2022
    4. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021
    5. The Pathobiology of Skin Aging American Journal Of Pathology · 2020
    6. Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia Scientific Reports · 2019
    7. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    8. Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope BioEssays · 2002