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GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations, December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations, October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research O-Glycosylated Cell Wall Proteins Are Essential in Root Hair Growth

274 citations, June 2011 in “Science”

Proteins with added sugars are crucial for plant root hair growth.

research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

22 citations, December 2017 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.

Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations, January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

38 citations, June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations, January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations, September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases During Postnatal Mouse Lung Development: A Cautionary Note

2 citations, October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

research Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

1 citations, July 2022 in “British Journal of Dermatology”

Targeting specific genes in certain pathways may help treat male pattern baldness.

research Topical Minoxidil in the Treatment of Androgenetic Alopecia in Women

7 citations, September 1991 in “PubMed”

research Effect of Minoxidil on Rabbit Lens Epithelial Cell Behavior In Vitro and In Situ

21 citations, September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology”

Minoxidil may help prevent capsular opacification after cataract surgery.

research Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development

25 citations, February 2017 in “Anticancer Research/Anticancer research”

Ozone therapy might improve cancer treatment and reduce its side effects.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations, March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research Collagen Involvement in Health, Disease, and Medicine

1 citations, March 2022 in “IntechOpen eBooks”

Collagen is crucial for health and treating certain diseases, and supplements can improve skin, nails, and hair conditions.

Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

research Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

1 citations, July 2023 in “International Journal of Molecular Sciences”

Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.

research 25 Years of Estrogen Receptor Beta: A Personal Journey

11 citations, September 2021 in “Journal of molecular endocrinology”

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

research Macrophage Ferroportin Is Essential for Stromal Cell Proliferation in Wound Healing

45 citations, August 2018 in “Haematologica”

Macrophage iron release is crucial for hair growth and wound healing.

research Mesenchymal Stem Cells Pretreated With Collagen Promote Skin Wound-Healing

6 citations, May 2023 in “International journal of molecular sciences”

Collagen-enhanced mesenchymal stem cells significantly improve skin wound healing.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations, August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Topical Niacinamide Does Not Stimulate Hair Growth Based on the Existing Body of Evidence

2 citations, January 2020 in “International Journal of Cosmetic Science”

Niacinamide does not promote hair growth.

research Hair Growth Effect and the Mechanisms of Rosa Rugosa Extract in DHT-Induced Alopecia Mice Model

October 2024 in “International Journal of Molecular Sciences”

Rosa rugosa extract promotes hair growth and could be a natural treatment for hair loss.

research FLCN Regulates Transferrin Receptor 1 Transport and Iron Homeostasis

1 citations, January 2021 in “Journal of biological chemistry/The Journal of biological chemistry”

FLCN helps control iron levels in cells.

COVID-19 Can Exacerbate Pattern Hair Loss and Trigger Telogen Effluvium: The Role of Proteoglycan Replacement Therapy with Nourkrin in Clinical Treatment of COVID-19 Associated Hair Loss

research COVID-19 Can Exacerbate Pattern Hair Loss and Trigger Telogen Effluvium: The Role of Proteoglycan Replacement Therapy with Nourkrin in Clinical Treatment of COVID-19 Associated Hair Loss

July 2021 in “Journal of dermatology research and therapy”

COVID-19 may worsen hair loss, and Nourkrin® could be a safe treatment option, but more research is needed.

research Translational Research in the Generation of Therapeutic Medicine for Wound Healing: A Review

December 2024 in “Deleted Journal”

New therapies show promise for wound healing, but more research is needed for safe, affordable options.

research Cellular Therapeutics and Immunotherapies in Wound Healing – On the Pulse of Time?

April 2024 in “Military Medical Research/Military medical research”

Cellular and immunotherapies show promise for healing chronic wounds but need more research.

research Calcium Regulation of Stem Cells

25 citations, May 2020 in “EMBO reports”

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

research Single-Cell Profiling Reveals a Potent Role of Quercetin in Promoting Hair Regeneration

10 citations, November 2022 in “Protein & Cell”

Quercetin significantly helps hair growth by activating hair follicles and improving blood vessel formation around them.