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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

Green tea extract helps prevent cell death and supports cell survival in hair cells exposed to a chemotherapy drug.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Menopause affects hair and skin; more research needed for treatment.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Thymosin β4 helps improve skin healing and reduce scarring.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

Women with AGA have more androstenedione and dihydrotestosterone, less copper and zinc; copper imbalance affects AGA; treatment improves hormones and minerals.