Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study

    January 2014 in “ International Journal of Endocrinology ”
    Rene Rodriguez-Gutierrez, Jesús Zacarías Villarreal-Pérez, Felipe Arturo Morales-Martínez, René Rodríguez-Guajardo, Gloria González-Saldivar, Leonardo Mancillas-Adame, Neri Alejandro Álvarez-Villalobos, Fernando J. Lavalle-Gonzalez, José Gerardo González-González
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    TLDR Women with a certain type of tumor had higher levels of pregnancy hormone and male hormones, which decreased after treatment.
    In the 2014 study involving 23 women with complete hydatidiform mole (HM) and 23 healthy pregnant controls, researchers discovered that before HM evacuation, the HM group had significantly higher levels of human chorionic gonadotropin (hCG), free testosterone, and dehydroepiandrosterone sulfate (DHEA-S) compared to the control group. There was a strong correlation between hCG and androgen levels. After HM treatment, hCG and androgen levels significantly decreased in the HM group. The study concluded that the ovaries and adrenal glands might be the source of androgen overproduction in HM cases, likely due to the stimulation of these glands by high hCG levels, a phenomenon referred to as the spillover effect. Clinical signs of hyperandrogenism were not observed, and hormone levels, including thyroid function, returned to normal two weeks post-evacuation.
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