Antiepileptogenic Effects of Trilostane in the Kainic Acid Model of Temporal Lobe Epilepsy

The study on 103 adult male Sprague Dawley rats found that trilostane did not affect the development of status epilepticus (SE) or hippocampal damage but significantly increased brain levels of allopregnanolone and suppressed pregnanolone synthesis. Repeated trilostane injections delayed the onset of seizures, suggesting its potential to modulate epileptogenesis, although a single injection was ineffective. These results indicate trilostane could be a promising agent for delaying epileptogenesis by increasing neurosteroid levels, particularly allopregnanolone.