Antiandrogen Treatment with Spironolactone and Linestrenol Decreases Bone Mineral Density in Eumenorrhoeic Women with Androgen Excess

    January 1994 in “ Hormone and Metabolic Research ”
    Janez Preželj, A Kocijancic
    Image of study
    TLDR Taking spironolactone and linestrenol for androgen excess can lead to lower bone density in young women.
    In a study from 1994, 17 young eumenorrhoeic women with androgen excess, with a median age of 22, were treated with spironolactone and linestrenol for one year, resulting in a significant decrease in bone mineral density (BMD). The mean BMD reduction was 0.032 g/cm² (p<0.001), with 15 of the 17 patients experiencing a decline. A significant correlation was found between the decrease in BMD and reduced androstenedione levels (r=0.5; p=0.037). These results highlight the need to consider the potential impact on BMD when prescribing antiandrogen treatment for functional hyperandrogenemia.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 416 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 1 month ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 1 month ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 4 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 9 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 11 months ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

    Related Research

    1 / 1 results