Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

This review examines the chemical composition and potential health risks of hair straighteners, but it reports no new findings and emphasizes the importance of understanding hair fibre structure for safe use.

This study identified two key pentapeptide quasi-repeats in human keratin-associated proteins, which are similar to motifs found in sheep wool.

This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.

Keratin structure changes during keratinization, but the exact model remains uncertain.

The authors conclude that optimizing hair shaft production and appearance may best be achieved by integrating biological, chemical, and physical intervention strategies.

This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.

This study found that Stat3 removal in keratinocytes of mice impairs healing and disrupts the normal hair cycle, leading to skin ulcers and hair loss as they age.

This study found that patients with alopecia areata had significantly higher serum MIF levels compared to healthy controls, which correlated with greater disease severity and duration.

This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.

In this study, researchers identified six unique genetic variants of a sheep gene, KRTAP19-3, with specific variants linked to changes in wool fibre traits, such as increased fibre diameter variability, suggesting these genetic differences affect wool characteristics in Chinese Tan sheep.

This review examines genetic variation in the ovine KRTAP1.1 gene and its potential impact on wool quality, reporting no new findings but suggesting opportunities for developing gene markers for wool and pelt traits.

In this study, maslinic acid applied topically was observed to stimulate hair growth in mice comparably to minoxidil, primarily activating pathways like Wnt/β-catenin, and suggesting a link between hair growth and cilia activity.

This study found that patients with trichodynia associated with androgenetic alopecia had significantly higher levels of substance P in both tissue and serum compared to healthy controls, suggesting a potential role for this neurotransmitter in the condition's pathogenesis.

This study developed a straightforward HPTLC method for detecting nicotine and cotinine in human plasma and urine, concluding that liquid-liquid extraction with methanol: chloroform: ammonia achieved optimal separation and is applicable for forensic analysis of lethal nicotine intoxication.

Mutations in the DSG4 gene cause specific hair and scalp issues.

This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.

In this study, a hydro-alcoholic extract of Urtica dioica demonstrated in vitro antioxidant activity, potentially linked to its ferulic acid content.

This review reports that cubosomes, used as drug nanocarriers in topical treatments, offer potential benefits for managing skin and eye diseases by improving bioadhesion, retention, and sustained release compared to conventional formulations, but also face manufacturing and biological challenges for effective clinical outcomes.

In this study, researchers isolated five new compounds from Monascus purpureus wmd2424 and found that four exhibited mild antifungal activity against several fungi.

This study found that microbial transformation of dihydrotestosterone with two types of fungi produced eight metabolites, among which metabolites 5–7 were significant inhibitors of butyrylcholinesterase, suggesting potential in Alzheimer's disease management.

This study identified a new ovine KRTAP21-1 gene variant in sheep, with wool yield affected by the variant, suggesting its potential as a genetic marker for improving wool production.

In this study on Chinese Tan sheep, researchers discovered a variant of the KRTAP19-5 gene associated with decreased curvature of fine wool fibres, highlighting potential genetic markers for improving wool quality.

This study found that post-COVID-19 telogen effluvium is strongly associated with elevated oxidative stress marker sRAGE and reduced antioxidant marker HO-1, suggesting potential biomarkers for early diagnosis and monitoring.

This study found that micro-computed tomography (micro-CT) was highly effective for analyzing the cross-sectional geometry of hair fibres, including the medulla in highly curled hair, but less effective than scanning electron microscopy for surface details.

This study identified a new gene in sheep, KRTAP36-2, discovering variants associated with wool yield. Variations in this gene were linked to the efficiency of fleece conversion from greasy to clean, which may enhance wool production.

In this study, researchers analyzed the skin proteome of Alpine Merino sheep to identify proteins and pathways related to wool fiber diameter, finding that cyclic adenosine monophosphate and certain signaling pathways may play a role in this trait.

This study describes a double embedding technique for preparing tangential sections of hair and wool fibers, recommending specific staining methods for quantitative analysis and demonstrating wool fiber cortical fractions.

This study observed that in mouse hair follicles, enzymes Aldh1a2 and Aldh1a3 have distinct expression patterns that suggest they are involved in different signaling pathways during the hair cycle.

Merino wool fibers change shape with moisture, while human hair shape stays the same.