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In this animal study, petroleum ether and ethanolic extracts of Abrus precatorius seeds appeared to reverse androgen-induced alopecia in male albino rats by inhibiting the 5α-reductase enzyme, similar to finasteride.

This study identified new oxidative derivatives of finasteride, including a newly discovered metabolite, by using the fungus Macrophomina phaseolina.

Keratin fibers in hair twist left-handed.

This study found that transcription factors HOXC13, LEF1, and FOXN1 repress DSG4 transcription, with the Notch pathway possibly involved in maintaining DSG4 expression in hair follicles.

This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.

This paper reviews the evolution of skin appendages and keratin-associated proteins among amniotes, proposing a model for their genetic divergence without new experimental results.

This review summarized advancements in intestinal lymphatic drug delivery, emphasizing the evolving understanding of lymphatics as active players in health and disease, which has led to innovative therapeutic strategies and enhanced pharmacokinetic outcomes via this delivery route.

This study successfully synthesized novel cercidin analogues from Cercidophyllum japonicum, confirming their structure via NMR data. The researchers suggest these compounds could facilitate future antibiotic development by advancing structure-activity-relationship studies.

This review discusses the genetic and biological factors influencing hair curliness, revealing strong links to specific protein variations, and reports no new clinical results.

This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.

This study found that cellular retinoic acid-binding proteins and fatty acid-binding proteins are dynamically expressed in skin development and respond differently to retinoic acid, β-catenin, and Notch signaling.

This study found that knocking down the gene SFRP1 in human hair follicles ex vivo prolonged the hair growth phase and increased keratinocyte proliferation, suggesting potential as a therapeutic target for maintaining hair growth in male pattern baldness, while DKK1 knockdown showed no effect.

Keratin-associated proteins are crucial for hair strength and structure.

This study demonstrated that anagen can be induced in Stat3-disrupted mice, suggesting that both Stat3-dependent and independent pathways, possibly involving PKC, mediate hair cycle progression with required PI3K activation.

This study concluded that the curliness of human hair, regardless of ethnicity, originates from the inhomogeneous internal nanostructure due to differences in the distribution of two types of cortices.

This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy.

This study identified polymorphisms in HGT-KRTAP7-1 and KRTAP8-1 genes in Argentine llamas that may impact fiber characteristics by altering amino acid residues critical for keratin-associated protein properties.

This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.

This study found that intradermal injection of Secreted Frizzled-related Protein 4 inhibits, but does not block, hair follicle regeneration in mice, suggesting potential therapeutic applications for hair follicle regeneration disorders.

This review explores the role of FGF signaling in hair follicle development and highlights its potential as a new therapeutic target for hair loss, which could surpass existing treatments in terms of efficacy and safety.

This study identified genetic mutations linked to congenital ichthyosis in families from the UAE and Turkey, revealing a connection between keratinization disorders and impaired filaggrin processing.

This study found that organ-cultured human scalp hair follicles can mimic chemotherapy-induced damage in vivo and serve as a model to explore molecular targets and protective agents for hair follicle preservation.

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

This study provides evidence supporting a regulatory relationship between the transcriptional regulator Hoxc13 and Krtap16 genes, which are crucial for proper hair growth in mice.

This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.

This review discusses the role of the unliganded vitamin D receptor in hair follicle cycling and tumor formation in mice and reports no new experimental findings.

In this proteomic analysis, the researchers found that transitioning from crimped to straight wool in Tan sheep is linked to significant changes in wool protein expression, revealing distinct patterns of keratins and keratin-associated proteins that could influence wool quality and economic value.