Intestinal Lymphatic Biology, Drug Delivery, And Therapeutics: Current Status And Future Directions

    August 2024 in “ Pharmacological Reviews ”
    Sanjeevini Babu Reddiar, Yining Xie, Mohammad Abdallah, Sifei Han, Luojuan Hu, Orlagh M. Feeney, Gracia Gracia, Abel Anshabo, Zijun Lu, Muhammad Asim Farooq, Ian K. Styles, Anthony R.J. Phillips, John A. Windsor, Christopher J. H. Porter, Enyuan Cao, Natalie L. Trevaskis
    TLDR The intestinal lymphatic system is active and promising for targeted drug delivery and therapies.
    The document reviews the evolving understanding of the intestinal lymphatic system, emphasizing its active role in biological and pathological processes, and its potential for targeted drug delivery. Historically seen as passive conduits, recent research highlights the lymphatics' dynamic nature, inspiring the development of lymph-specific therapies and advanced drug delivery strategies, including nanotechnologies and lipid-conjugated materials. The review discusses the anatomy and physiology of the gastrointestinal lymphatic system, current drug delivery approaches, and the pharmacokinetic and therapeutic benefits of targeting the intestinal lymphatics. It also suggests future directions for enhancing the clinical application of these strategies.
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