Ovine KRTAP36-2: A New Keratin-Associated Protein Gene Related to Variation in Wool Yield

November 2023 in “ Genes ”

Huitong Zhou, Wenhao Li, Lingrong Bai, Jiqing Wang, Yuzhu Luo, Shaobin Li, Jon G.H. Hickford

Studysummary This study identified a new gene in sheep, KRTAP36-2, discovering variants associated with wool yield. Variations in this gene were linked to the efficiency of fleece conversion from greasy to clean, which may enhance wool production. Our plain-language summary of this paper — not a Tressless recommendation.

The study identified a new keratin-associated protein gene in sheep, KRTAP36-2, which is linked to variations in wool yield. Researchers screened 170 sheep and found four gene variants. In 274 Southdown × Merino lambs, the presence of variant A was associated with a decrease in wool yield, indicating that KRTAP36-2 affects the quantity of non-fibre wool components. The findings suggest that this gene could be targeted to enhance wool production, though further investigation is needed to understand the underlying mechanisms.

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research The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes

10 citations , November 2021 in “International journal of molecular sciences”

This review discusses the role of keratin-associated proteins in the growth and characteristics of wool and hair fibres from sheep and goats, and highlights areas for future research, but it presents no new findings.

research Characterization of an Ovine Keratin Associated Protein Gene, Producing a Protein Rich in Glycine and Tyrosine, Lacking in Cysteine

24 citations , October 2019 in “Genes”

In this study, the identification of a novel KAP gene in sheep, named KRTAP36-1, was associated with increased prickle factor in wool, suggesting its potential as a genetic marker for breeding purposes.

research Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits

7 citations , July 2019 in “Animals”

This study identified a new ovine KRTAP21-1 gene variant in sheep, with wool yield affected by the variant, suggesting its potential as a genetic marker for improving wool production.

research Variation In The Ovine Keratin-Associated Protein 15-1 Gene Affects Wool Yield

18 citations , September 2018 in “The Journal of Agricultural Science”

In this study, the presence of certain KAP15-1 gene variants in sheep was associated with differences in wool yield and fiber characteristics.

research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits

42 citations , January 2017 in “Genes”

This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.

research Wool Keratin-Associated Protein Genes in Sheep: A Review

98 citations , May 2016 in “Genes”

This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.

research Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression

83 citations , May 2011 in “Experimental Dermatology”

In this study, researchers identified nine new sheep keratin genes, highlighting species-specific differences in the expression and compartmentalization of wool-related keratin genes compared to humans.

research Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1

50 citations , July 2008 in “British Journal of Dermatology”

research Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog

70 citations , February 2007 in “Journal of Investigative Dermatology”

K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

51 citations , January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.

Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered