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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

Keratin 79 is linked to liver damage and may help diagnose liver diseases.

Not having the gene PLAAT3 leads to fat loss, high insulin resistance, and abnormal fat levels in the blood due to a disruption in fat cell development and function.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

Fat cells help recruit healing cells and build skin structure during wound healing.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

PPAR alpha may help in hair growth and could be a target for treatment.

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.

The research found that a protein called PPARg is important for the formation and healing of sebaceous glands, which can regenerate independently from hair follicles.

Bezafibrate treatment improved skin and spleen health in aging mice but didn't extend lifespan.

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

Adipocytes can change into fibroblast-like cells to help with wound healing.

The hexosamine pathway helps protect skin cells from stress and may improve skin and hair health.

PGD2 stops hair growth and is higher in bald men with AGA.

Fat cells in the skin help start healing and form important repair cells after injury.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Hair loss in certain young mice is linked to a specific gene and can be caused by lack of iron.

Eclipta alba extract may help treat obesity by blocking fat cell formation and lowering blood lipid levels.