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Effective treatment guidelines for frontal fibrosing alopecia are still unclear.

GPR40 agonists help hair growth through the protein ANGPTL4.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Increased PPARGC1α relates to hair thinning in common baldness.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

Caffeine can protect scalp hair follicles from damage caused by UV radiation.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

The T-zone on the face has more androgen receptors and produces more oil than the U-zone.

Aquaporins could be new drug targets for treating polycystic ovary syndrome.

Eating less can improve stem cell function and increase lifespan.

Fat under the skin can help hair grow longer, darker, and increase cell growth.