305 citations
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July 2016 in “International Journal of Biological Macromolecules” This review describes the roles of polysaccharides in antitumor, antiviral, and anti-inflammatory activities and introduces methods for their isolation and purification, reporting no new research results.
125 citations
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December 2016 in “Molecules” This review discusses the extraction, purification, modification, and biological activity of polysaccharides from Traditional Chinese Medicine and reports no new research findings.
59 citations
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August 2014 in “International Journal of Biological Macromolecules” In this study, the researchers optimized the extraction conditions for crude polysaccharide from Hibiscus rosa-sinensis leaves, achieving a yield of 9.66% and demonstrated strong antioxidant activities in vitro.
49 citations
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October 2024 in “Frontiers in Immunology” In this review, the authors highlighted the potential of natural polysaccharides from plants, animals, and microbes to modulate immune responses, reduce inflammation, and strengthen the intestinal barrier, suggesting their promising role as immunomodulatory agents in pharmaceutical applications.
45 citations
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January 2021 in “Stem Cell Research & Therapy” This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.
31 citations
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January 2011 in “Journal of Biomaterials and Nanobiotechnology” This paper describes the development of unique hydrogel skin scaffolds from plant-derived polysaccharide mixtures that may offer improved biocompatibility and mechanical properties for use in artificial skin.
2 citations
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June 2023 in “Plants” This paper reviews extraction methods for obtaining polysaccharides from brown macroalgae like Sargassum, highlighting their antiviral, antimicrobial, and antitumoral bioactivities in both in vivo and in vitro studies, while also discussing challenges in research and commercialization of Sargassum-based products.
1 citations
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October 2024 in “Journal of Clinical Immunology” This study observed that adult Netherton syndrome patients showed a range of normal to diminished immune responses to polysaccharide, conjugate, and mRNA-based vaccines, with responses generally overlapping those of healthy controls, suggesting no consistent B- or T-cell immunodeficiency in this population.
July 2025 in “Journal of Investigative Dermatology” In this study, AMP-303 injections demonstrated a trend toward increasing non-vellus hair count in men with mild to moderate androgenetic alopecia, notably showing a 14.5% peak increase at 60 days compared to saline, with effects lasting up to five months.
December 2022 in “Korean journal of medicinal crop science/Han-gug yagyong jagmul hag-hoeji” This study found that polysaccharide extracts from ginseng, green tea, shiitake, and aloe vera effectively protected human follicle dermal papilla and keratinocyte cells by promoting cell proliferation or inhibiting apoptosis, suggesting potential for these extracts as ingredients in cosmetics or pharmaceuticals to prevent hair loss.
April 2011 in “HAL (Le Centre pour la Communication Scientifique Directe)” This study suggests that polymersomes decorated with chitosan improve the transdermal delivery of finasteride, providing an alternative drug delivery system with higher drug retention in the skin.
May 2026 in “International Journal of Biological Macromolecules” In this study, researchers developed a biomacromolecular hydrogel to deliver plant-derived extracellular vesicles for treating androgenetic alopecia in a mouse model, which significantly improved hair regrowth and follicle density by activating Wnt/β-catenin signaling.
August 2023 in “Processes” This study found that fermenting Dendrobium officinale with Lactiplantibacillus plantarum CCFM8661 and other strains increased polysaccharide yields and skin care activity, particularly with CCFM8631, which showed significant improvements in skin cell protection and inflammation reduction in both cell cultures and mouse models.
October 2024 in “International Journal of Biological Macromolecules” This review discusses recent advances in extracting, purifying, and analyzing polysaccharides from Ginkgo biloba leaves, which are valued in traditional Chinese medicine for their diverse biological activities, including antioxidant and hair-growth promoting effects, aiming to inform future development and commercialization.
130 citations
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December 2022 in “Antioxidants” This review discusses the antioxidant activity of natural polysaccharides, highlighting their potential applications in areas like drug delivery and tissue engineering, but reports no new experimental findings.
19 citations
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April 2021 in “Journal of Cosmetic Dermatology” This study found that a hair care treatment using integral silk proteins and linseed-derived polysaccharides effectively protected and repaired bleached and colored hair swatches, significantly improving their resistance, luster, and reducing structural damage after chemical treatments.
14 citations
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March 2025 in “Nano Today” The hydrogel dressing speeds up and improves diabetic wound healing.
14 citations
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November 2020 in “International Journal of Biological Macromolecules” This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.
10 citations
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January 2025 in “Biomaterials Science” This study found that a multifunctional hydrogel dressing enriched with Cu-MOF and tannic acid significantly improved full-thickness wound healing in rats, reducing the wound area to only 1.6% and promoting re-epithelialization, neovascularization, and hair follicle formation.
1 citations
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December 2023 in “Egyptian Journal of Veterinary Science” In this study, researchers found that a nanoparticle gel derived from Astragalus polysaccharides improved wound healing significantly more than a Gold-Silver nanocomposite gel and untreated controls, with better wound closure observed by the 15th day.
1 citations
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June 2023 in “Journal of Cellular and Molecular Medicine” This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.
January 2026 in “Advanced Healthcare Materials” This study developed a 3D-printed scaffold for diabetic wound repair, which showed potential in a mouse model by reducing inflammation, promoting blood vessel regeneration, enhancing skin hydration, and accelerating wound healing through nitric oxide and gallium ion release, oxidative stress modulation, and antioxidant pathway activation.
December 2025 in “ACS Applied Bio Materials” This study demonstrated that an aloe polysaccharide-collagen wound dressing improved wound healing by enhancing angiogenesis and reducing inflammation in vivo.
September 2025 in “ACS Applied Polymer Materials” This study reported that a composite hydrogel made with Chlorella-derived extracellular polysaccharide–selenium nanoparticles showed strong antibacterial and anti-inflammatory effects in vitro and significantly accelerated wound healing in vivo, offering potential for managing infected wounds and monitoring healing progression.
July 2025 in “Carbohydrate Polymers” This study investigated the extracellular polysaccharides from the edible green alga Parachlorella sp. BX1.5, finding that they have potential applications in cosmetics and health products due to their stability, antioxidant properties, and effects on hair growth in mice.
March 2025 in “Stem Cell Research & Therapy” This study found that microneedles containing magnetic intracellular vesicles and tremella polysaccharide improved the hair microenvironment and accelerated hair regeneration in mice with androgenic alopecia.
January 2013 in “Shiyong yixue zazhi” In this study with mouse follicle stem cells, astraglus polysaccharide increased markers of cell proliferation and gene expression, suggesting a potential mechanism for treating alopecia and promoting hair growth.
February 2026 in “PubMed” This study reported that polysaccharides from Astragalus roots could promote hair regeneration and optimize drug delivery when combined in innovative microneedles, effectively improving hair growth in mice with androgenetic alopecia.
100 citations
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December 2021 in “Biomedicine & Pharmacotherapy” This review examines advancements in natural polymer-based drug delivery systems like hydrogels and composites for treating major diseases, highlighting challenges in solubility and functionalization but reports no new clinical results.
45 citations
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January 2020 in “Pharmaceutical Biology” This review discusses the potential dermatological applications of Dendrobium officinale polysaccharides, noting their hair growth promoting, skin moisturizing, and antioxidant effects, but reports no new clinical results.