3D-Printed Hydrating Masque for Diabetic Wound Repair: A Nitric Oxide-Enhanced Tremella Polysaccharide-Based Scaffold for Improved Wound Comprehensive Regulation

The study presents a novel 3D-printed scaffold, LZ@TMG, designed for diabetic wound repair, leveraging the moisturizing properties of tremella polysaccharides (TP). This scaffold incorporates nitric oxide (NO) nanoreactors and gallium ions to form a composite bioink, which is 3D-printed to release NO and Ga3+ for bacterial inhibition and modulation of oxidative stress and inflammation. In a mouse model, the scaffold demonstrated reduced inflammation, enhanced blood vessel and hair follicle regeneration, improved skin hydration, and accelerated wound healing. The study highlights the scaffold's potential as a multifunctional tool for effective moist wound healing in diabetes.