75 citations
,
September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
64 citations
,
January 2009 in “Canadian Journal of Gastroenterology” This review discusses various presentations of drug-induced cutaneous eruptions, particularly those associated with interferon and ribavirin, and reports no new clinical findings.
63 citations
,
June 2023 in “Journal of Nanobiotechnology” In this study, researchers developed a 3D chitosan/polyvinyl alcohol-tannic acid nanofiber sponge that demonstrated effective hemostatic, antibacterial, and antioxidant properties without antibiotics, accelerated wound healing in vivo, and showed high biocompatibility with L929 cells, highlighting its potential as a wound dressing for clinical use.
61 citations
,
September 2024 in “Micromachines” This paper provides a comprehensive overview of the applications of electrospun nanofibers in non-invasive medical fields, highlighting their potential for health monitoring, personal protection, thermal regulation, and wound care, and discusses the challenges and future development paths for this technology.
61 citations
,
April 2023 in “Bioactive Materials” This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.
60 citations
,
February 2015 in “Biomaterials” In this study, immobilized VEGF selectively captured endothelial cells under various shear stresses, suggesting its potential for promoting endothelialization in vascular grafts or implanted tissues.
50 citations
,
February 2022 in “Nanomaterials” This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.
49 citations
,
January 2023 in “Gels” This review summarizes recent advancements in three-dimensional bioprinting technology and hydrogel bioinks, highlighting their applications in tissue engineering, but reports no new experimental results.
47 citations
,
October 2021 in “Journal of Nanobiotechnology” This study found that hollow polydopamine nanoparticles enhanced the regenerative potency of the peptide RL-QN15, suggesting potential for improved therapeutic approaches in skin wound healing.
46 citations
,
January 2020 in “Research” This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.
46 citations
,
October 2018 in “Neuroscience Bulletin” 40 citations
,
April 1999 in “Journal of Histochemistry & Cytochemistry” In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.
39 citations
,
February 2024 in “Small” This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.
37 citations
,
December 2022 in “Acta Pharmaceutica Sinica B” This review discusses the strategies and potential of CRISPR delivery for gene therapy, highlighting the challenges and innovative use of stimuli-responsive nanocarriers, but reports no new experimental results.
37 citations
,
December 2020 in “PLANT PHYSIOLOGY” In this study, the researchers identified a temperature-sensitive mutant in Arabidopsis thaliana, showing disrupted root hair formation and altered responses to plant hormone treatments at elevated temperatures.
36 citations
,
August 2020 in “Polymers” The researchers developed semi-dissolving microneedle patches using TEMPO-oxidized bacterial cellulose nanofibers, which allow effective transdermal drug delivery by forming micro-channels for large drug quantities, overcoming traditional microneedles' low drug loading.
35 citations
,
November 2024 in “Gels” This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.
35 citations
,
February 2022 in “Frontiers in Pediatrics” This study found that tofacitinib may be effective in treating various pediatric rheumatic diseases, particularly juvenile idiopathic arthritis, although some patients did not respond, and side effects were observed.
32 citations
,
August 2016 in “Science Signaling” This study developed PiSCES biosignatures that distinguished alopecia areata patients from controls, revealing enhanced basal TCR signaling and a potential disease-specific signaling network signature.
30 citations
,
July 2023 in “Journal of Cutaneous Medicine and Surgery” This article emphasizes the need for dermatology to treat gender identity, gender, and sex as distinct factors, aiming to improve patient-specific risk assessment and treatment alignment, and highlights a research gap in distinguishing sex and gender as separate risk factors in the field.
27 citations
,
September 2015 in “Drug Design Development and Therapy” This study suggests that type IV collagenases, MMP-2 and MMP-9, play important roles in the hair cycle by regulating the expression of VEGF, IGF-1, and TGF-β in mice.
26 citations
,
April 2024 in “Particle and Fibre Toxicology” In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.
26 citations
,
July 2023 in “International Journal of Nanomedicine” The researchers suggest that combining microneedle technology with nanocarriers could enhance drug delivery systems for treating central neurological diseases due to nanoparticles' ability to prolong blood circulation time and improve brain targeting.
24 citations
,
November 2023 in “Regenerative Biomaterials” In this review, the authors summarized the potential therapeutic effects of metal ions in treating cardiovascular diseases, highlighting their roles in protecting cells, inducing angiogenesis, and adjusting ion channel functions, as well as discussing delivery strategies involving biomaterials.
24 citations
,
February 2021 in “Polymers” This study found that urchin-like Ag–Au bimetallic and Ag nanoparticle-decorated PAN mats showed significant antibacterial effects and potential for wound healing in in vitro and in vivo animal models.
22 citations
,
August 2015 in “PloS one” This study found that the binding and release of BMP-2 from kerateine biomaterials are significantly influenced by pH and salt concentration, highlighting the potential for developing improved bone repair systems.
22 citations
,
December 2013 in “Stem cells and development” This study found that treating skin wounds with a combination of epidermis-derived epithelial-like stem/progenitor cells and platelet-rich plasma improved tissue repair and increased vascularization and elastin content compared to platelet-rich plasma alone.
21 citations
,
March 2025 in “Journal of Extracellular Vesicles” This review discusses how using hydrogels as a three-dimensional culture platform for mesenchymal stem cells might affect the production of extracellular vesicles, highlighting challenges in standardization and opportunities to boost EV yield via combined hydrogels and bioreactor methods.
21 citations
,
June 2024 in “Pharmaceuticals” This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.
21 citations
,
December 2023 in “Bioengineering & Translational Medicine” This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.