Equine Epidermis: A Source of Epithelial-Like Stem/Progenitor Cells with In Vitro and In Vivo Regenerative Capacities

The study identified and characterized a subpopulation of stem/progenitor cells derived from equine epidermis, known as epithelial-like stem/progenitor cells (EpSCs), which showed potential for skin regeneration. These cells were confirmed as EpSCs based on their expression of specific markers and demonstrated self-renewal and differentiation capabilities. In a comparative healing experiment involving six full-thickness skin wounds on horses, three wounds treated with a combination of EpSCs and platelet-rich plasma (PRP) showed improved healing outcomes compared to the three wounds treated with PRP alone. The EpSC/PRP-treated wounds had a thinner dermis, less granulation tissue, increased vascularization, higher elastin content, and more follicle-like structures, indicating that EpSCs, when used in conjunction with PRP, could enhance tissue repair in vivo.