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Increased ODC activity leads to skin tumors by recruiting stem cells, not by toxic byproducts.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

Some minoxidil combinations can help differentiate leukemia cells without harming other cells.

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

Altering SSAT affects fat metabolism and body fat in mice.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

Putting α-methylspermidine on mouse skin can start hair growth.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

An enzyme other than TNAP might be responsible for vitamin B-6 metabolism in the skin.

OM-X® helped prevent negative effects of Vitamin C deficiency in mice, suggesting it could protect organs and regulate metabolism.

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

T cells and bacteria in the gut and skin help maintain health and protect against disease.

Increasing SSAT makes skin more prone to cancer.

Overexpression of SSAT in mice causes hair loss, liver damage, and sensitivity to polyamine analogues.

Adjusting polyamine levels could help treat skin disorders like psoriasis and skin cancer.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

The studies identified key factors and potential treatments for skin and hair disorders.

Spermidine may help reduce hair loss and deserves further testing as a treatment.

Polyamines help fix DNA damage accurately in cells.

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.