In This Issue

May 2001 in “ Journal of Investigative Dermatology ”

Leena Bruckner‐Tuderman

keratinocyte growth factor granulocyte macrophage-colony stimulating factor putrescine polyamine metabolism all-trans retinoic acid fibrillin-1 photoaging retinoic acid retinol

TLDR The studies identified key factors and potential treatments for skin and hair disorders.

The document discussed several studies related to skin and hair conditions. One study used genetically modified mouse fibroblasts to explore keratinocyte growth and differentiation, identifying granulocyte macrophage-colony stimulating factor and keratinocyte growth factor as key mediators. Another study investigated hairlessness in transgenic mice, linking it to overaccumulation of putrescine due to altered polyamine metabolism, which affected the hair cycle. Additionally, a study on photoaging demonstrated that all-trans retinoic acid could repair photoaged skin by increasing fibrillin-1 production, suggesting its potential as a marker for evaluating skin repair treatments. These findings provided insights into molecular mechanisms and potential therapeutic strategies for skin and hair disorders.

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research Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture

April 2019 in “Journal of Investigative Dermatology”

The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.