November 2021 in “Authorea (Authorea)” This case report suggests that platelet-rich plasma and hair transplantation may trigger or worsen the progression of cutaneous pseudolymphoma to lymphoma, particularly in patients with a family history.
April 2026 in “Journal of Craniofacial Surgery” This pilot study found that plasma- and sonophoresis-assisted delivery of an exosome-containing formulation improved hair and scalp metrics over 12 weeks, with short-term safety observed, but controlled trials are needed for confirmation.
November 2025 in “Advanced Science” In this study, researchers found that a cold atmospheric plasma-activated hydrogel containing interleukin-2 significantly enhanced hair regeneration in a depilated mouse model, promoting larger hair follicles and faster hair growth phase transition, suggesting it as a potential treatment for hair loss.
166 citations
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August 2011 in “Dermatologic Surgery” This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.
November 2025 in “Journal of Microbiology and Biotechnology” In this study, combining Botulinum toxin type A with Platelet-rich plasma was found to enhance hair follicle growth and reconstruction, potentially through inflammation reduction and activation of the Wnt/β-catenin pathway via STMN1 protein modulation.
33 citations
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February 2019 in “Journal of Tissue Engineering and Regenerative Medicine” This review discusses the use of platelet-rich plasma for various dermatological conditions and highlights the need for more research to standardize its protocols and understand its biological mechanisms.
13 citations
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July 2012 in “Dermatologic Surgery” Platelet-rich plasma (PRP) may help promote hair growth and improve graft survival after hair transplantation, but more research is needed to confirm its effectiveness and determine the best dosage.
1 citations
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January 2016 This review discusses the diverse applications of platelet-rich plasma in tissue repair, aesthetic medicine, and hair restoration, but reports no new clinical results.
August 2024 in “OBM Transplantation” This article reviews the use of platelet concentrates in regenerative medicine and highlights the need for standardized protocols and more specific clinical studies, without reporting new clinical results.
205 citations
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April 2013 in “British Journal of Dermatology” In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.
October 2022 in “Hair Transplantation” This study reviewed preliminary evidence suggesting platelet-rich plasma could play a significant role in hair restoration, with animal experiments showing faster hair cycle transitions compared to controls.
115 citations
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August 2020 in “International Journal of Molecular Sciences” This systematic review indicates that a platelet-rich plasma concentration of 1.0 × 10^6 plt/μL may be optimal for tissue regeneration due to sufficient nutrition supply and effective growth factor diffusion in vivo.
1 citations
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October 2021 in “Cureus” This study found that platelet-rich plasma treatment led to significant reductions in lesion sizes for both plaque psoriasis and atopic dermatitis, with many patients achieving complete remission and no adverse events reported.
September 2024 in “Revista Foco” This review discusses the applications of platelet-rich plasma in aesthetic medicine, highlighting its potential for facial rejuvenation, scar treatment, and combating alopecia, but reports no new results.
119 citations
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January 2014 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the use of platelet-rich plasma in various dermatological applications and reports no new clinical results; the authors call for more rigorous trials to confirm its effectiveness.
May 2026 in “Medical Sciences” This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.
June 2023 in “Journal of Burn Care & Research” This study found that combining bone marrow aspirate concentrate with platelet-rich plasma significantly improved wound healing in mice compared to other treatments.
3 citations
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January 2023 in “PloS one” In this study, hair-follicle-associated pluripotent stem cell implantation improved functional recovery and reduced inflammation in a mouse model of intracerebral hemorrhage.
1 citations
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January 2020 in “Aesthetic Surgery Journal” Platelet-rich plasma and stem cell therapies are accepted treatments for hair restoration, with specific protocols recommended for best results, but more standardization is needed in stem cell use.
19 citations
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May 2019 in “Journal of Cosmetic Dermatology” In this study, both platelet-rich plasma and intralesional corticosteroids improved hair re-growth in alopecia areata patients, but the difference between treatments was not significant, with fewer relapses observed in the platelet-rich plasma group.
March 2023 in “Medica Hospitalia: Journal of Clinical Medicine” In this study, PRP treatment significantly promoted hair regrowth in patients with alopecia areata, with the best outcomes occurring after 4-6 sessions.
This study summarizes the therapeutic use of mesotherapy using vitamins, trace elements, and stem cell extracts for treating alopecia, noting its effectiveness in addressing both androgenetic alopecia and telogen effluvium as demonstrated in various clinical trials.
62 citations
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November 2022 in “Acta Pharmaceutica Sinica B” This study reported that an injectable hydrogel based on platelet-rich plasma and laponite improved wound healing in diabetic and normal rats by enhancing angiogenesis and macrophage polarization.
3 citations
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January 2000 This chapter discusses various substances and therapies for dermatological applications, including heliotherapy, UVB, khellin, and others, but reports no new research findings.
April 2023 in “The Egyptian Journal of Hospital Medicine” The study found that intralesional injection of platelet-rich plasma appears safe and may be effective for treating post-burn scars, with shorter scar durations showing better results.
2 citations
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January 2023 in “Revista Interfaces Saúde Humanas e Tecnologia” This review discusses platelet-rich plasma's potential for aesthetic procedures like facial rejuvenation and alopecia treatment but reports no new clinical findings; further research is needed.
September 2026 in “Russian Journal of Skin and Venereal Diseases” In this study, photodynamic therapy combined with platelet-rich plasma showed potential for greater efficacy than photodynamic therapy alone in treating androgenic alopecia, with both approaches improving hair density without serious side effects.
This review explores the clinical applications of platelet rich plasma therapies across several fields and suggests potential future research directions for cord blood platelet rich plasma.
2 citations
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September 2024 in “World Journal of Clinical Cases” This case report describes how autologous platelet-rich plasma treatment led to complete healing of a chronic wound in a 72-year-old male patient after other standard treatments failed.
5 citations
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January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This study found that PRP was effective for treating alopecia areata with similar improvement across groups, while topical delivery via fractional CO2 laser or microneedling reduced injection pain.