Plasma-Rich Protein and ACell

October 2022 in “ Hair Transplantation ”

platelet-rich plasma ACell androgenetic alopecia female pattern hair loss alopecia areata post-hair transplant surgery neovascularization growth factors cytokines stem cells dermal papilla cells fibroblast growth factor 7 beta-catenin telogen phase anagen phase PRP

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study reviewed preliminary evidence suggesting platelet-rich plasma could play a significant role in hair restoration, with animal experiments showing faster hair cycle transitions compared to controls.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Platelet-rich plasma (PRP) was identified as a promising treatment for various medical and dermatological conditions, including hair loss. It was considered a simple, cost-effective, and feasible option for conditions like androgenetic alopecia, female pattern hair loss, alopecia areata, and post-hair transplant surgery. PRP worked by stimulating new follicle development and promoting neovascularization through growth factors and cytokines acting on stem cells. It increased the proliferation of dermal papilla (DP) cells and activated signaling pathways, with fibroblast growth factor 7 and beta-catenin upregulated in DP cells. In mice, PRP injections accelerated the transition from telogen to anagen phases compared to controls, suggesting its potential role in hair restoration.

View this study on thieme-connect.de →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Understanding Autoimmunity of Vitiligo and Alopecia Areata

74 citations , May 2016 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics”

This review identifies shared interferon gamma-driven immune pathways in vitiligo and alopecia areata, revealing potential targets for new treatments, but reports no clinical results.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

This study found that platelet-rich plasma significantly increased hair density and anagen hair proportions in androgenetic alopecia patients, suggesting potential as an adjuvant therapy.

Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

research Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

39 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that intra-operative platelet-rich plasma therapy may enhance hair regrowth, increase graft density, and activate dormant follicles more effectively than normal saline in follicular unit extraction hair transplant patients.

research Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

30 citations , August 2015 in “JAAD case reports”

This case report describes a patient with corticosteroid-resistant ophiasis alopecia areata who experienced prompt hair regrowth after receiving platelet-rich plasma injections.

research The Human Hair: From Anatomy to Physiology

107 citations , December 2013 in “International Journal of Dermatology”

This review summarizes the anatomical and physiological aspects of human hair and its clinical significance, but does not report new research findings.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , August 2011 in “Dermatologic Surgery”

This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.

research Preliminary Experience and Extended Applications for the Use of Autologous Platelet-Rich Plasma in Hair Transplantation Surgery

18 citations , July 2007 in “Hair transplant forum international”

This study reported that using platelet-rich plasma as a storage medium for hair grafts in hair restoration surgery may improve graft survival rates and accelerate healing.