Plasma-Rich Protein and ACell

October 2022 in “ Hair Transplantation ”

platelet-rich plasma ACell androgenetic alopecia female pattern hair loss alopecia areata post-hair transplant surgery neovascularization growth factors cytokines stem cells dermal papilla cells fibroblast growth factor 7 beta-catenin telogen phase anagen phase PRP

TLDR PRP is a promising, cost-effective treatment for hair loss by stimulating hair growth.

Platelet-rich plasma (PRP) was identified as a promising treatment for various medical and dermatological conditions, including hair loss. It was considered a simple, cost-effective, and feasible option for conditions like androgenetic alopecia, female pattern hair loss, alopecia areata, and post-hair transplant surgery. PRP worked by stimulating new follicle development and promoting neovascularization through growth factors and cytokines acting on stem cells. It increased the proliferation of dermal papilla (DP) cells and activated signaling pathways, with fibroblast growth factor 7 and beta-catenin upregulated in DP cells. In mice, PRP injections accelerated the transition from telogen to anagen phases compared to controls, suggesting its potential role in hair restoration.

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Research cited in this study

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research Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

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A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , August 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

research Preliminary Experience and Extended Applications for the Use of Autologous Platelet-Rich Plasma in Hair Transplantation Surgery

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research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

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Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

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