Search
for
Sort by
Research
120-150 / 1000+ results
research Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders
This review examines how different prostanoids and their receptors affect hair growth but provides no new clinical results; it highlights potential implications for treating hair disorders.
research Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease
This study found that platelet-rich growth factor significantly reduced the release of proinflammatory cytokines in an in vitro rheumatoid arthritis model.
research TLR3 signaling modulates immunomodulatory property of human periodontal ligament stem cells.
This study found that activating Toll-like receptor 3 signaling in periodontal ligament stem cells may enhance their immunomodulatory properties, suggesting potential implications for future stem cell therapy applications.
research Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair
This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.
research PV-0538 Prostaglandin related distinct regenerative activities in hair follicles following radiation injury
HPV infection is linked to better survival in advanced anal cancer, higher radiation doses improve survival, especially in HPV-negative patients, and prostaglandin E₂ pretreatment can protect mouse hair follicles from radiation damage.
research 743 Adipocyte stem cells are maintained by Pdgfα signaling in the skin
This study found that Pdgfα signaling is crucial for maintaining dermal adipose tissue in mice by initiating dermal adipocyte stem cell proliferation, with implications for age-related skin defects.
research Prostaglandin E 2 Receptor 2 Modulates Macrophage Activity for Cardiac Repair
This study found that EP 2 signaling is crucial for macrophage recruitment and inflammatory regulation in the injured heart, impacting cardiac repair processes.
research PDGF isoforms induce and maintain anagen phase of murine hair follicles
This study found that injecting PDGF-AA and -BB into mouse skin immediately triggered the hair growth cycle's anagen phase, suggesting potential treatment options for certain types of alopecia.
research Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle
This study used infrared spectral imaging to show for the first time the distribution of glypican-4 and glypican-6 in hair follicles across different growth phases, highlighting the potential of this technique for studying alopecia.
research Expression of the guinea-pig alpha-lactalbumin gene in transgenic mice
This study found that guinea pig α-lactalbumin transgene was expressed in the mammary glands and sebaceous glands of transgenic mice, with milk protein production occurring in the expected secretory acini.
research Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation
This study found that gelatin microspheres loaded with platelet-rich plasma enhanced wound healing in rats by improving inflammatory and angiogenic responses compared to untreated wounds or PRP alone.
research A small multigene hydroxyproline-O-galactosyltransferase family functions in arabinogalactan-protein glycosylation, growth and development in Arabidopsis
This study provides evidence that five Hyp-O-GALT genes are crucial for AGP galactosylation and that AGP glycans are vital for various aspects of plant growth and development.
research Presentation1.PPTX
This study found that GPC1 is a significant regulator of angiogenesis in human dermal microvascular endothelial cells, suggesting its potential as a target for alopecia research.
research Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics
This review discusses the roles of various PLA2 enzymes in skin health and disease, highlighting potential pathways for future diagnosis and therapy, but it reports no new clinical results.
research Diguanoside tetraphosphate (Gp₄G) is an epithelial cell and hair growth regulator.
This study found that Gp₄G increased hair length, papilla cell numbers, and versican deposition in treated animals, potentially through alterations in hair follicle phases and nucleotide concentrations.
research INDUCTION OF PSORIASIFORM CHANGES IN GUINEA PIG SKIN BY PROPRANOLOL
This study found that while the combination of oral propranolol and intradermal injections in guinea pigs led to psoriasiform changes, it did not fully mimic psoriasis.
research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.
In this study, the researchers found distinct patterns of TGF-beta 1 and IGF-II expression in pig fetal subcutaneous tissue, suggesting specific regulatory roles in developing adipocytes and muscle tissue.
research Gli2-serpinh1 drives fibroblast state transition during skin wound healing
This study identified a crucial Gli2-Serpinh1 regulatory axis that regulates fibroblast state transitions during skin wound healing, shedding light on fibroblast heterogeneity and suggesting potential precision regenerative therapies.
research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1
This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.
research CGF therapy: bridging androgenetic alopecia observations to psoriasis treatment via IL-17 pathway
This study found that CGF may be effective in reducing inflammation and improving skin conditions in psoriasis, particularly in patients resistant to other treatments.
research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6
This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.
research Group IID, IIE, IIF and III secreted phospholipase A2s
This article reviews the roles of lesser-known secreted phospholipase A2 isoforms in various biological processes, such as immune suppression, metabolic regulation, epidermal hyperplasia, and male reproduction, without reporting new clinical findings.
research Protoporphyrin IX: the Good, the Bad, and the Ugly
This review discusses the mechanisms associated with protoporphyrin IX in living cells and reports no clinical results; the authors emphasize its potential in cancer diagnosis and the risks of toxicity.
research Evidence for murine cutaneous immune surveillance localized to hair follicle epithelium
This study found that PGRP-S expression in mouse epidermis is specific to certain hair follicle epithelia, depending on the skin region, and can be transiently induced in flank skin hair follicle epithelium after exposure to Staphylococcus aureus, suggesting a role in environmental surveillance.
research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata
This study found that total glucosides of paeony (TGP) reduced hair loss and inflammation in alopecia areata mice by inhibiting cellular pyroptosis.
research Triton modified polyethyleneimine conjugates assembled with growth arrest-specific protein 6 for androgenetic alopecia transdermal gene therapy
In this study, researchers developed a promising transdermal agent using Triton X-100-modified polyethyleneimine that successfully delivered genetic material to hair follicle cells in mice, potentially alleviating hair loss due to androgenetic alopecia by promoting cell proliferation and inhibiting apoptosis.
research Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition
This study found that inhibiting the PI3Kδ enzyme in murine models of cutaneous chronic graft-versus-host disease (cGVHD) reduced skin scores and fibrosis, prevented pathogenic lymphoid structures, and improved survival, suggesting it as a promising therapeutic approach to address the disease's hypoxic pathophysiology.
research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation?
This study found that the selective PPARγ modulator GMG-43AC may inhibit unwanted hair growth by inducing catagen phase while preserving hair follicle epithelial progenitor cells, suggesting potential in anti-hirsutism therapy.
research 15-Hydroxyprostaglandin Dehydrogenase Inhibitor Restores Endothelial Function Under Dihydrotestosterone-Induced Stress in Human Dermal Microvascular Endothelial Cells
This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.