Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes Under Inflammatory Joint Disease

This study investigated the effects of platelet-released growth factor (PRGF) on human synoviocytes in an in vitro rheumatoid arthritis (RA) model. Researchers stimulated synoviocytes with 10 ng/ml TNF-α, which significantly increased the secretion and gene expression of proinflammatory cytokines IL-6 and TNF-α. Treatment with PRGF demonstrated an anti-inflammatory effect by significantly reducing TNF-α and IL-1β levels, suggesting that PRGF could inhibit the release of proinflammatory cytokines under inflammatory conditions. The study concluded that further research was needed to fully understand the mechanisms by which PRGF affects synoviocytes.