Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs

The document reviews the use of platelet-rich derivatives, particularly platelet-rich fibrin (PRF), in cartilage and joint repairs. PRF is a second-generation platelet concentrate that promotes tissue regeneration through its fibrin matrix enriched with platelets and growth factors. It is highlighted for its simplified preparation, safety, and cost-effectiveness compared to platelet-rich plasma (PRP). PRF has shown promise in enhancing cartilage repair, stimulating chondrocyte viability, and providing a bioactive scaffold for regeneration. Despite its advantages, there is variability in treatment outcomes, and further research is needed to optimize its clinical applications. The document also notes the need for standardized preparation protocols due to inconsistencies in clinical results and emphasizes the potential of PRF in musculoskeletal and maxillofacial applications.