Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs

Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has shown promise in tissue regeneration due to its high concentrations of growth factors and anti-inflammatory cytokines, which aid in vessel formation, cell proliferation, and differentiation. PRF's autologous nature and minimally invasive application make it safe for clinical use, particularly in musculoskeletal, oral, maxillofacial surgeries, and dermatology. The narrative review highlights PRF's potential as an adjuvant in treating chronic muscle, cartilage, and tendon injuries, though further clinical trials are necessary to confirm its benefits.