Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease Through PI3Kδ Inhibition
November 2024
in “
Blood
”
Studysummary This study found that inhibiting the PI3Kδ enzyme in murine models of cutaneous chronic graft-versus-host disease (cGVHD) reduced skin scores and fibrosis, prevented pathogenic lymphoid structures, and improved survival, suggesting it as a promising therapeutic approach to address the disease's hypoxic pathophysiology.
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