Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study concluded that both pure-PRP and leukocyte-PRP injections significantly reduced serum CD 68 levels in knee osteoarthritis patients, with pure-PRP being more effective than leukocyte-PRP.

In this experimental study, laser irradiation significantly altered the gene expression of cytokines in cultured human T-cell lymphocytes, suggesting that such laser light may photobiomodulate cytokine production in vitro.

This study found that a new SIS-PEG sponge promoted rapid skin defect healing in mice and showed potential for reconstructing reconstituted skin with regenerated hair.

In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.

This study found that transgenic expression of COX-2 in mouse basal keratinocytes causes epidermal hyperplasia and certain dysplastic features at specific body sites.

This review highlights important studies in regenerative medicine, including one where PDGF and FGF2 synergistically maintained hair inductive potential in mouse dermal papilla cells in vitro, with potential implications for human hair loss therapy. It reports no new experimental results, focusing instead on existing research findings.

In this study, researchers synthesized biomedical polyurethanes incorporating curcumin and varying PEG content to enhance water solubility and control curcumin release, finding that higher PEG content improved hydrophilicity, swelling, and degradation, while maintaining excellent antioxidant and antibacterial activities, suggesting promise for biomedical applications.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

In this case report, a three-generation family with Gorlin-Goltz syndrome showed a heterozygous PTCH1 splice-donor variant associated with the disease, and two affected relatives benefited from individualized, side-effect-guided dosing of the drug sonidegib, experiencing regression of basal cell carcinoma lesions.

The study suggests that variability in platelet-derived growth factors in PRP is influenced by both patient-to-patient differences and the devices used for PRP preparation, contributing to inconsistent clinical outcomes in hair loss treatments.

This study found that injecting PRP gel derived from a patient's own blood may promote tissue regeneration and closure of intestinal fistulas unresponsive to conservative therapy.

This study found that GALT5 and GALT2 are redundant enzymes essential for O-glycosylation of AGPs, with mutations leading to significant growth and development defects in plants.

The enzyme PA-PLA1α is important for proper hair follicle development.

In this study, pioglitazone treatment in patients with lichen planopilaris showed limited success, with significant improvement seen in only a minority of cases.

In this study, researchers developed EPO-derived peptides that enhanced hair growth by stimulating dermal papilla cells and increasing IGF-1 expression without triggering systemic erythropoietic effects in tested models, indicating a promising approach for treating hair loss.

This study observed that PCE-DP may improve skin pigmentation by increasing epidermal turnover and inhibiting melanin uptake and inflammation in human epidermal keratinocytes.

This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.

This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.

This study found that keratinocyte growth factor is a potent mitogen in human hyperplastic prostate cells, suggesting it plays an important role in prostate growth by acting in a paracrine manner.

This study suggests that human dermal papilla cells respond to hypoxia by increasing the expression of HIFs, TGF-β2, and BMP4, which may influence hair cycle regulation.

This study suggests that IGF-1, a component of human placenta hydrolysate, promotes hair growth by increasing the number and size of hair follicles in mice.

In this study, l-Ascorbic acid 2-phosphate was found to stimulate hair follicle growth in vitro by promoting IGF-1 expression via the PI3K pathway.

In this study, Thy-1 was observed to play a critical role in wound healing in mice, particularly influencing vascular dynamics and blood perfusion during the healing process.

This study found that in a human skin organ culture model of pemphigus vulgaris, split formation led to significant upregulation of IFNγ and TNFα-related genes, indicating secondary effects from mechanical stress, not direct changes from autoantibodies.

This study suggests that IL-1β may play a role in inflammatory signaling pathways in papulopustular rosacea, contributing to its pathogenesis.

This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.

This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.

This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.