TLDR Papulopustular rosacea is an inflammatory skin condition treatable with lifestyle changes and medications.
The "SnapshotDx Quiz: January 2021" from the Journal of Investigative Dermatology focused on diagnosing papulopustular rosacea (PPR), a chronic inflammatory condition. The study highlighted the role of IL-1β in PPR, showing that IL-1β treatment induced a transcriptional and proteomic signature of the disease in nonlesional skin. Researchers found upregulation of the MAPK and TNF signaling pathways in PPR skin explants. Treatment recommendations included avoiding environmental triggers, using gentle skin hygiene, and applying topical or oral medications like ivermectin, azelaic acid, and tetracycline antibiotics.
43 citations,
November 2018 in “Nature Communications” Genetic variations affecting skin structure play a key role in severe acne.
148 citations,
February 2005 in “Autoimmunity Reviews” Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.
13 citations,
November 2021 in “Frontiers in Immunology” Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.
2 citations,
May 2023 in “Frontiers in Pharmacology” Natural products may help treat skin inflammation from abnormal adrenal hormones.
3 citations,
December 2022 in “Cells” Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.
January 2023 in “International Journal of Molecular Sciences” Maxillariinae orchids contain 62 compounds with potential health benefits, including treating skin conditions and diseases like cancer and diabetes.
1 citations,
October 2020 in “PubMed” Azelaic acid helps protect hair cells from UV damage and encourages hair growth by increasing certain gene expressions and proteins.
