Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue
June 1998
in “
The Journal of Clinical Endocrinology & Metabolism
”
TLDR KGF and its receptor are found in enlarged prostate tissue and KGF strongly increases cell growth.
In 1998, a study by Alessandra De Bellis and colleagues explored the expression of Keratinocyte Growth Factor (KGF) and its receptor (KGF-R) in benign prostatic hyperplasia (BPH) tissue. They discovered that KGF and KGF-R transcripts were present in all BPH tissues examined, with KGF mRNA primarily in stromal cells and KGF-R mRNA mainly in the epithelium. The study demonstrated that KGF significantly stimulated the proliferation of cultured BPH cells, more so than other growth factors like bFGF and EGF, with the greatest effect at a concentration of 10 ng/mL. These findings support the idea that KGF acts as a key mitogen for BPH cells through a paracrine mechanism and may be involved in the indirect control of epithelial cell proliferation by androgen. The number of BPH tissues analyzed was not specified in the summary.
