Effect of Diode Pumping Solid State Laser with Wavelength 589 nm on Gene Expression of Interleukin-2 and Interferon-Gamma in Human T-Lymphocytes

The study conducted at Mustansiriyah University examined the impact of a 589 nm diode pumping solid state laser on the gene expression of interleukin-2 (IL-2) and interferon-gamma (IFN-y) in human T-lymphocytes. Using blood samples from healthy individuals, the research found significant increases in IL-2 and IFN-y expression, particularly at laser doses of 30J/cm² for in-plate irradiated cells and 70J/cm² for whole blood samples. The findings suggest that laser irradiation can modulate cytokine production and gene expression, with effects dependent on exposure conditions. However, the study's conclusions are limited by an uncalculated sample size, indicating the need for further clinical research to explore therapeutic applications.