77 citations
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January 1980 in “Carcinogenesis” This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.
March 2014 in “Chinese Journal of Dermatology” This study found that dermal papilla cells from different scalp regions of AGA patients showed differential gene expression related to cell proliferation, apoptosis, and signaling pathways when exposed to DHT in a 3D culture.
This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.
3 citations
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August 2024 in “The Journal of Cell Biology” This study demonstrated that in live rodents, actin filaments adjust their structure to facilitate membrane transfer between cellular compartments with different biophysical properties.
4 citations
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August 2022 in “The Scientific World Journal” This study found that bufotalinin, derived from Merremia peltata leaves, may enhance hair growth by acting as a potential androgen receptor antagonist in rabbits.
September 2025 in “Development” In this study, deleting the transcriptional pause factor Nelfb in mouse preadipocyte lineages led to defective dermal fat formation and lethal outcomes, while interventions targeting Pparg could rescue adipocyte differentiation and promote dermal white adipose tissue formation, underscoring Nelfb's critical role in adipogenesis.
2 citations
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January 2022 in “Oxidative Medicine and Cellular Longevity” This study suggests that exosomes from dermal papilla cells can regulate hair follicle stem cell proliferation via the Wnt3a/β-catenin signaling pathway, potentially informing treatment for human hair problems.
January 2005 in “Industrial Catalysis” This study found that regenerating the Pd/C finasteride synthesis catalyst using methanol extraction and nitric acid oxidation achieved a pregnendone conversion of 97.5%.
April 2018 in “Journal of Investigative Dermatology” In this study, TRPV3G568V mice exhibited periodic hair loss and immune cell infiltration in the dermis, without affecting hair follicle stem cell fate, suggesting a focus on dermal immune cells for future research.
1 citations
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May 2022 in “Голова и шея.” This study observed a strong positive association between the expression of the p53 protein and the appearance of dark neurons in the hippocampus of rats following experimental septoplasty, suggesting p53's potential neuroprotective role alongside its activation of damaged neurons.
February 2019 in “Journal of Physiology & Pathology in Korean Medicine” In this study, the ethanol extract of Puerariae Radix was found to promote proliferation and ERK activation in human dermal fibroblasts, suggesting its potential as a new cosmetic ingredient.
June 1967 in “Journal of Cellular Physiology” This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.
45 citations
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August 1994 in “Journal of Chromatography B: Biomedical Sciences and Applications” Method detects finasteride in plasma and semen with high sensitivity and accuracy.
17 citations
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May 2011 in “Gene Therapy” This study found that transfecting hair follicle stem cells with a PEI-DNA complex expressing hTERT stimulated hair growth in rats by inducing follicle neogenesis and promoting the anagen phase.
478 citations
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September 1996 in “Proceedings of the National Academy of Sciences” This study found that overexpression of PTHrP in mice chondrocytes led to short-limbed dwarfism and delays in endochondral ossification, highlighting PTHrP's role in inhibiting chondrocyte differentiation.
36 citations
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December 2002 in “Experimental dermatology” This study found that procyanidin B-3, a compound isolated from barley extract, may promote hair growth by enhancing hair epithelial cell growth and counteracting TGF-β1's growth-inhibiting effects in vitro and in vivo.
3 citations
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July 2021 in “Life science alliance” This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.
9 citations
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July 2007 in “Circulation Research” This study found that disruptions in planar cell polarity signaling are implicated in congenital heart defects and cardiomyopathy in developing mouse hearts, associated with early cardiomyocyte disorganization and improper heart looping.
3 citations
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May 2019 in “Journal of Cosmetic Dermatology” This study suggests that the dipeptide Pro-Ile has FGF18-like activity, can penetrate model human epidermis, and may have potential as a cosmetic ingredient for skin and hair regulation.
June 2020 in “Acta Scientific Otolaryngology” This case study presents a patient with male-pattern alopecia who received PRP treatment with calcium chloride after ruling out other potential causes.
February 1999 in “Analytical Sciences” A new antiandrogen compound was made and its detailed three-dimensional shape was described.
July 2024 in “Journal of Investigative Dermatology” In this animal study, researchers found that the simultaneous deletion of ERBB2 and ERBB3 in mice results in impaired skin differentiation, inflammation, and sebaceous gland alteration, leading to skin lesions, while highlighting potential side effects in cancer therapies targeting these receptors.
December 1998 in “福井大学教育学部紀要 第4部 教育科学” This study found that the bioconjugate nanoparticle HA-P5 significantly alleviated acne and reduced sebum production by inhibiting key signaling pathways without inducing unwanted protein expression that hinders acne treatment.
84 citations
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June 2010 in “The Plant Cell” In this study, disruptions in phospholipase A2 activity in Arabidopsis thaliana significantly impaired the plasma membrane localization of PIN proteins, affecting auxin transport and root development.
July 2024 in “Journal of Integrative Plant Biology” This study found that soybean plants maintain root hair growth under phosphate deficiency by using two vacuolar Pi efflux transporters, GmVPE1 and GmVPE2, to remobilize stored Pi, with the process regulated by the GmRSL2 transcription factor.
5 citations
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November 2022 in “Journal of Ginseng Research/Journal of ginseng research” This study investigated the role of autophagy in human dermal papilla cells and found that inhibiting autophagy accelerates the catagen phase by reducing Wnt/β-catenin signaling. Furthermore, adding ginsenoside Re appears to restore autophagy, suggesting potential benefits for mitigating hair loss linked to autophagy inhibition.
January 2007 in “Chinese Journal of Analysis Laboratory” This study proposed a method to determine residual levels of dichloromethane and chloroform in finasteride using SPME-GC, reporting high linear correlation coefficients for both solvents.
September 2022 in “European Journal of Dermatology” This study identified a novel pathogenic splice-site variant of the LAMB3 gene in patients with junctional epidermolysis bullosa, highlighting the importance of gene sequencing for diagnosis.
124 citations
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July 1997 in “Journal of Biological Chemistry” This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.