Cosmetic Potency of Puerariae Radix in Dermal Fibroblasts

February 2019 in “ Journal of Physiology & Pathology in Korean Medicine ”

Jae Yun Lee, Seo A Park, Won Hong Woo, Yeun Ja Mun

Puerariae Radix ethanol extract of Puerariae Radix collagenase 5α-reductase I 5α-reductase II ERK activation PD98059

TLDR Puerariae Radix extract may be a promising cosmetic ingredient for skin health.

The study investigated the cosmetic potential of ethanol extract of Puerariae Radix (EPR) on human dermal fibroblasts, revealing that EPR suppressed collagenase activity and inhibited 5α-reductase I and II at 25 μg/ml. It also promoted cell proliferation and ERK activation, which was blocked by the ERK inhibitor PD98059, indicating that EPR's effects were mediated through ERK activation. These findings suggested that EPR could be a promising new cosmetic ingredient.

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