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This study found that mutations in type I IRS keratin genes disrupt keratin protein complexes in mice, suggesting crucial roles for these genes in proper hair coat formation.

This study found a previously unreported ST14 gene mutation in a patient with ichthyosis-hypotrichosis syndrome, highlighting novel skin and hair characteristics and emphasizing the critical role of the Asp482 amino acid in matriptase activation.

This study proposed a network model for the cross-linked structure of keratin-associated proteins in hair and wool fibers, suggesting notable differences between the two, potentially affecting hair fiber elasticity.

This study identified the expression sites of five KAP5 genes on human chromosome 11q13.5 in scalp skin sections but did not explore their detailed distribution within hair follicles.

This article reports that mutations in the PADI3 gene, affecting its activity or localization, cause uncombable hair syndrome and are linked to central centrifugal cicatricial alopecia, particularly among women of African ancestry.

This study found that the catalytically inactive serine protease CAP1/Prss8 can still induce skin disorders in mice and is subject to inhibition by nexin-1, independent of its catalytic activity.

Hair follicles have unique proteins that vary by species and are influenced by nutrition.

This study suggests that the absence of alpha5(IV)/alpha6(IV) chains in certain subepidermal basement membrane spots may relate to interactions with melanocytes in human skin.

Bioactive peptides improve graft survival and new hair growth.

This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.

This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.

This study found that Hairless (HR) and putrescine form a negative regulatory network that impacts epidermal homeostasis and hair follicle cycling, linked to the MYC superfamily's regulation of ODC expression.

This review examines glycopeptide hydrogels as biomimetic materials for tissue regeneration and other biomedical applications, describing their design, properties, and potential uses, and highlighting future advancements in replicating natural tissue environments for precision medicine.

This study observed that putrescine and HR form a negative feedback mechanism affecting hair cycling, indicating a significant connection between HR, polyamines, and hair growth regulation.

This study observed that in chicken skin, large-scale differences in gene expression between feathered and scaly skin are controlled by enhancer-driven uniform expression, while small-scale differences within individual feathers are associated with chromatin looping.

This study mapped 65 intermediate filament genes in the human genome, highlighting that the majority of keratin-related sequences are inactive pseudogenes, notably for keratins 8 and 18.

This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.

This study found that human hair cuticle and cortex have different protein structures, with beta-sheet and disorder configurations in the cuticle and alpha-helical structures in the cortex.

In this study, the researchers cloned and analyzed the CRABP I gene in Inner Mongolian cashmere goats, finding its highest mRNA expression at 90 days in embryo skin compared to later stages.

The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.

This review highlights the potential of peptide-based PROTACs (pPROTACs) in expanding the target range of protein degraders beyond small-molecule limitations, particularly for undruggable proteins, by utilizing advances in design, conjugation, and bioPROTAC technology.

This study analyzed the distribution of adhesion molecules and extracellular matrix components in human fetal skin, suggesting their roles in hair follicle development.

This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.

This study found that specific proteins associated with fiber structure, hair growth, and fatty acid synthesis, including the DSC2 gene, may influence wool and hair characteristics in sheep and goats.

TAT-GILZ peptide promotes hair growth by boosting stem cell activity.

This study found that a specific fragment of AIMP1, secreted by hair follicle stem cells, activated dermal papilla cells, leading to enhanced hair regrowth and maintenance in mice.

This study found that shorter CAG-repeat lengths in the androgen receptor may be associated with the development of androgen-mediated skin disorders like androgenetic alopecia, acne, and hirsutism in both men and women.