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research A review on formulation and analytical aspect of mangiferin a natural phenolic xanthonoid
This review highlights that although mangiferin, a polyphenol from the mango tree, faces challenges like low solubility and bioavailability, delivery vehicles such as nanoparticles and complexes have the potential to enhance its therapeutic effectiveness in treating various diseases.
research Smoothened antagonists for hair inhibition
This study found that aminomethylpyrazole compound 10l inhibited hair growth in a mouse model and showed a low risk for photo-irritation, though it was slightly less effective than eflornithine.
research A randomized, placebo- and active-controlled, parallel-group, multicenter, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis
This study found that the novel antifungal emulsion NB-002 demonstrated significant antifungal activity and nail clearing in patients with distal subungual onychomycosis involving ≤50% of the nail.
research LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo
PP405 may help hair growth by activating hair follicle stem cells.
research A rapid method for obtaining finasteride, a 5α-reductase inhibitor, from commercial tablets
Quickly get finasteride from tablets using easy methods.
research Tofacitinib for the treatment of lichen planopilaris: A case series
This study found that treatment with oral tofacitinib, alone or with other therapies, was associated with clinical improvement in most patients with recalcitrant lichen planopilaris.
research An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
In this study, oral Pycnogenol® intake was reported to significantly increase hair density and improve scalp microcirculation in Han Chinese menopausal women over six months.
research Evaluation of utility of phenol in alopecia areata
This study found that 88% phenol treatment significantly improved texture, pigmentation, and density of hair regrowth in alopecia areata patients over nine weeks, with 78% showing a good to excellent response.
research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level
This study found that some synthesized 17-oximino-5-androsten-3β-yl esters demonstrated stronger cytotoxicity and antiandrogenic activity against prostate cancer cells than finasteride.
research Anti-Alopecia Activity of Coumarin Derivatives Isolated from Merremia peltata Leaves and Computational Study of Their Binding to Androgen Receptors Using Molecular Docking and Molecular Dynamic Simulation
This study evaluated the anti-alopecia activity of compounds from Merremia peltata leaf in rabbits and found that scopolin has a promising effect on hair growth and androgen receptor affinity, potentially offering a new treatment option for alopecia.
research Structural characterization and dissolution profile of mycophenolic acid cocrystals
This study found that the cocrystal of mycophenolic acid with isonicotinamide significantly improved solubility and dissolution rate, while two other cocrystals showed decreased performance in these areas.
research Bimatoprost in androgenic alopecia dermatologic treatment
This study found that prototype right heart circulatory assist devices significantly improved hemodynamics and reduced pulmonary vascular resistances in piglet models of acute hemodynamic shock.
research Comparative study of the chemical profile, cytotoxic activity, and molecular docking of Serenoa repens extract and a pharmaceutical product
This study found that the extracts of Serenoa repens, when evaluated through chemical, biological, and in silico methods, demonstrated anti-inflammatory, pro-apoptotic, and anti-androgenic activities against prostate cancer cell lines, suggesting potential therapeutic benefits and directing future pharmaceutical development.
research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.
This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.
research Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases
This study suggests that targeting olfactory receptors in the lung epithelium might help treat odorant-induced asthma in cases without type 2 inflammation, as these receptors could play a role in airway sensitivity to smells.
research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth
In this study, procyanidin B-2 and C-1 were found to promote hair growth by selectively inhibiting protein kinase C, supporting their potential use for hair-growing activity.
research Sensitive bromatometric assay methods for finasteride in pharmaceuticals
This study developed three spectrophotometric methods to effectively measure finasteride in bulk and tablet forms, providing accurate results that align closely with labeled claims.
research Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle
This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.
research Metabolic profiling by LC-DAD-MS, FTIR, NMR and CE-UV of polyphenols with potential against skin pigmentation disorder
This study observed that the aqueous extract of roasted Alocasia macrorrhizos tubers led to hair follicle repigmentation and reduced epidermal thickness in a murine model of Vitiligo.
research PHENOLIC COMPOUND CONTENT, ANTIOXIDANT AND RADICAL-SCAVENGING PROPERTIES OF METHANOLIC EXTRACTS FROM THE SEED COAT OF CERTAIN THAI TAMARIND CULTIVARS
This study found that Sithong-bao seed coat extract, with high phenolic content, exhibited the strongest antioxidant properties among certain Thai tamarind cultivars, suggesting potential for nutraceutical development.
research Modified phenol peels for treatment‐refractory hyperpigmentation of lichen planus pigmentosus: A retrospective clinico‐dermoscopic analysis
This study found that six sessions of a modified phenol peel effectively reduced hyperpigmentation in patients with Lichen Planus Pigmentosus, with 76% of treated individuals experiencing at least a 25% improvement, and no serious side effects reported.
research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis
In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.
research Identification and in-silico analysis of phytochemicals from Phyla nodiflora (L.): Potential bioactive compounds for therapeutic applications
This study investigated the therapeutic potential of phytochemicals from Phyla nodiflora, identifying 50 bioactive compounds through GC-MS analysis. Among them, n-hexadecanoic acid, stigmasterol, and beta-sitosterol showed promise in molecular docking studies as drug candidates for diabetes, alopecia, cancer, and anti-diuresis.
research Formulasi Hair Tonic Ekstrak Etanol Kulit Buah Pepaya (Carica Papaya L.) dan Uji Efektivitas Pertumbuhan Rambut pada Marmut Jantan (Cavia porcellus)
This study found that a hair tonic made with 30% ethanol extract from papaya fruit peel effectively promoted hair growth in guinea pigs, with results close to those of a positive control, and contains beneficial compounds like alkaloids and flavonoids.
research UJI AKTIVITAS PERTUMBUHAN RAMBUT KELINCI JANTAN DARI SEDIAAN HAIR TONIC YANG MENGANDUNG EKSTRAK ETANOL DAUN MANGKOKAN (Nothopanax scutellarium L.)
In this study, researchers found that hair tonic formulations containing Nothopanax scutellarium extract enhanced hair growth in male rabbits over 21 days, with the 25% concentration showing comparable effects to a minoxidil-based positive control.
research Improved Cardiovascular Effects of a Novel Pomegranate Byproduct Extract Obtained through Hydrodynamic Cavitation
This study investigated a novel extract from pomegranate byproducts, finding it effective in reducing blood pressure and inflammation in hypertensive rats, comparable to Captopril, while also highlighting the extract's potential to enhance the pomegranate supply chain and environmental benefits.
research Literature Review: Nutrafol® vs. Microinflammation
This article discusses a novel multi-targeting approach to treating hair loss using standardized nutraceuticals but reports no new clinical results.
research Diagnosis dan Farmakoterapi Penyakit Paru Obstruktif Kronis
This review discusses personalized treatment strategies and management approaches for chronic obstructive pulmonary disease (COPD), emphasizing the need for multi-aspect assessments, but reports no new clinical findings.