A Review on Formulation and Analytical Aspect of Mangiferin, a Natural Phenolic Xanthonoid

May 2025 in “ Discover Chemistry. ”

Imran Shaikh, Hemant Kumar Tatapudi

Studysummary This review highlights that although mangiferin, a polyphenol from the mango tree, faces challenges like low solubility and bioavailability, delivery vehicles such as nanoparticles and complexes have the potential to enhance its therapeutic effectiveness in treating various diseases. Our plain-language summary of this paper — not a Tressless recommendation.

This review discusses the challenges and solutions related to the use of mangiferin, a polyphenol from the mango tree with significant pharmacological benefits, as a nutraceutical. Despite its potential, mangiferin's low solubility and bioavailability limit its effectiveness. The review highlights how various delivery vehicles, such as complexes and different types of nanoparticles, can enhance mangiferin's solubility and therapeutic effects. Additionally, it covers the analytical methods used to estimate mangiferin in different matrices, emphasizing the importance of overcoming these pharmaceutical challenges to improve its efficacy in treating various diseases.

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