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In this study, dry powder inhalers containing Cepharanthine were administered to rats with acute lung injury, significantly reducing pulmonary edema, hemorrhage, and inflammatory markers, suggesting its potential as an effective anti-inflammatory treatment when inhaled directly into the lungs.

This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.

This study identified a new compound from fermented Carica papaya L. with moderate antioxidant and potent hair growth-stimulating activities in vitro.

In this study, DPHC from the brown alga Ishige okamurae demonstrated potential to prevent androgenic alopecia by inhibiting hair loss and promoting hair growth through multiple cellular mechanisms.

This study found that indole glycosides from Calanthe discolor Lindl. can significantly promote the proliferation of human hair follicle dermal papilla cells, potentially through upregulating specific growth factors.

This study identified six molecules from herbal extracts that effectively bind to 5-alpha reductase (5-AR), with Jomogenin showing high binding stability when encapsulated in lipid nanoparticles, suggesting their potential for further experimental analysis to aid hair follicle growth.

In this study, petroleum ether extracts of Phyllanthus niruri promoted hair regrowth in testosterone-induced alopecia in rats by inhibiting the 5α-reductase enzyme.

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

In this study, candidate compound 39 demonstrated potent androgen receptor antagonism and faster hair-growth efficacy in a mouse model compared to pyrilutamide, while maintaining favorable safety and pharmacokinetic profiles, suggesting potential for topical use in androgenic alopecia.

This study successfully synthesized novel cercidin analogues from Cercidophyllum japonicum, confirming their structure via NMR data. The researchers suggest these compounds could facilitate future antibiotic development by advancing structure-activity-relationship studies.

This study found that calanthoside, a compound isolated from Calanthe species, promotes the proliferation of human hair follicle dermal papilla cells more effectively than minoxidil.

This study found that Pleuropterus cilinervis extracts and animal milk fermented with Lactobacillus rhamnosus promoted hair growth in mice, suggesting potential applications in hair loss treatments.

This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.

In this study, researchers found that applying topical aprepitant, which blocks substance P receptors, significantly reduced facial dermatitis and hair loss in rats experiencing erlotinib-induced skin side effects, highlighting the neurogenic inflammation's role and the protective effect of ROS inhibition.

In this study, BP201, derived from porcine lung phospholipids, promoted hair growth in mice, especially when combined with minoxidil, and increased hair follicle numbers and dermal papilla cell proliferation.

This study reported that using piroctone olamine in either a shampoo or leave-on product form significantly increased hair retention and improved scalp condition in women with perceived hair thinning.

This study found that both alcoholic and aqueous extracts of Punica granatum L. showed potential for promoting hair growth and exhibited anti-lice and antidandruff activities in a mouse model.

In this case report, the authors describe using Polarity Analysis for selecting homeopathic remedies to better match patient symptoms in treating alopecia areata, offering a potential alternative to corticosteroids, which are associated with significant side effects.

This review highlights Croton tiglium's dual therapeutic and toxic properties, noting its potential for hair growth promotion through PKC-mediated pathways, while emphasizing the challenges posed by its toxicity for safe clinical use.

In this pilot study, topical latanoprost acid was observed to increase hair count and improve hair follicle structure in women with androgenetic alopecia, with no serious adverse events, suggesting potential for further investigation to confirm its efficacy and safety.

Tavaborole is a safe and effective toenail fungus treatment, with the 5% solution being the best option.

In a hair-growth mouse model, this study reported that the novel AR antagonist candidate 39, derived from structural optimization of 14-P1, achieved similar efficacy to pyrilutamide with faster response and maintained safety, demonstrating potent AR antagonism and favorable pharmacokinetics with lower systemic toxicity risk.

This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.

This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.

In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

This review discusses finasteride's use in manipulating neuroactive steroid levels and its potential effects on behavior, reporting preclinical evidence and clinical observations but providing no new experimental results.

In this study, researchers optimized the extraction conditions for polyphenols from the medicinal herb Eclipta prostrata, achieving the highest polyphenol content under specific conditions of temperature, solvent concentration, and time, and found the extract to have significant antioxidant activity.

This study observed that a combination of sinapic acid and glabridin from Zhimo herbal extract improved hair growth and reduced oxidative stress in a DHT-induced model of androgenetic alopecia in mice by preventing ferroptosis and stabilizing β-Catenin, offering potential application for AGA treatment.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.