Novel Dual Soft Drug Strategy Enables Development of Topical Androgen Receptor Antagonists with Enhanced Efficacy and Optimized Safety for Androgenetic Alopecia

    July 2026 in “ Journal of Medicinal Chemistry ”
    Y Zhang, Wenqiang Zhang, Feng Tang … Yu Jiao
    Studysummary In this study, candidate compound 39 demonstrated potent androgen receptor antagonism and faster hair-growth efficacy in a mouse model compared to pyrilutamide, while maintaining favorable safety and pharmacokinetic profiles, suggesting potential for topical use in androgenic alopecia.
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    Research cited in this study 22

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