98 citations
,
July 1968 in “Archives of Dermatology” This study found that applying scalp sebum from young men to rabbit ear canals caused follicular hyperkeratosis, suggesting sebum stimulates the formation of comedones, a key feature in acne vulgaris.
72 citations
,
July 1984 in “Journal of Investigative Dermatology” 
63 citations
,
February 2013 in “Human cell” In this study using an animal model, researchers found that PEGL-DOX, unlike DOX, causes Hand-Foot Syndrome due to reactive oxygen species interacting with skin tissue, leading to skin-specific inflammatory responses.
63 citations
,
May 2009 in “Dermato-endocrinology” This review explores the role of FGFR2b-signaling in the pathogenesis of acne, highlighting its influence on sebaceous gland physiology and the effects of anti-acne agents like isotretinoin.
60 citations
,
January 1989 in “Toxicologic Pathology” This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
52 citations
,
April 2004 in “Journal of The American Academy of Dermatology” This article proposes three mechanisms by which dihydrotestosterone may contribute to baldness but reports no new research findings.
36 citations
,
July 1988 in “Archives of Dermatological Research” Pili annulati is caused by a protein metabolism disorder affecting hair structure.
35 citations
,
March 1976 in “British Journal of Dermatology” This study observed no correlation between Demodex species and skin condition among Aborigines, though D. brevis was associated with sebaceous gland degeneration in one case.
34 citations
,
January 2018 in “International Journal of Dermatology” This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.
23 citations
,
July 1994 in “Journal of Dermatological Science” This study found that the twisted hair shafts characteristic of pili torti may result from uneven outer root sheath cell development, leading to irregular hair shaft modeling and twisting.
19 citations
,
August 2018 in “JAMA dermatology” This study found that skin mesenchymal stem cells from hidradenitis suppurativa patients overexpress proinflammatory and anti-inflammatory cytokines, suggesting their potential contribution to the disease's pathogenesis.
12 citations
,
December 2011 in “Canadian Journal of Microbiology” In this study, all five serotypes of Ureaplasma were found to be pathogenic in a mouse model of lower genital tract infection, with serotype 4 showing the greatest pathogenicity.
9 citations
,
March 1999 in “Der Hautarzt” Type 2 5α-reductase plays a key role in hair loss.
6 citations
,
January 2005 in “Biology of Blood and Marrow Transplantation” This article reviews various models of graft-versus-host disease, highlighting the complexity of its mechanisms and the challenges in interpreting histopathologic data; it reports no new results.
4 citations
,
September 2022 in “Experimental and Сlinical Urology” This review examines the use of 5-alpha-reductase inhibitors for treating benign prostatic hyperplasia, noting moderate positive effects without complete cure and the need for further research to understand drug mechanisms and pathogenesis.
1 citations
,
January 2025 in “International Journal of Dermatology” This study found that in patients with alopecia areata and atopic dermatitis, 61.5% showed improvement with dupilumab treatment, but 38.5% experienced worsened or new-onset alopecia areata, with higher baseline IgE levels linked to better responses.
1 citations
,
June 2024 in “Access Microbiology” This study found that certain non-dermatophytic moulds, specifically *Absidia* sp., *Cladosporium tenuissimum*, and *Aspergillus welwitschiae*, can cause skin symptoms such as discoloration and lesions in albino mice, suggesting potential virulence due to enzyme activity.
1 citations
,
January 2006 This article reviews the pathophysiology and causes of androgen-mediated hair growth in hirsutism but does not report any clinical outcomes; treatment aspects are discussed separately.
1 citations
,
August 1981 in “The Journal of Dermatology” This study reported that defects in the hair cuticle were found in every case of major structural hair abnormalities examined.
December 2025 in “Babcock University Medical Journal” This study found that in patients with Alopecia Areata, CD27 and IL-35 levels were significantly higher in those with bacterial infections, suggesting they may be useful as immunological biomarkers.
January 2025 in “Dermatologic Therapy” In this review, researchers explored key mechanisms underlying androgenetic alopecia, revealing how hormonal, oxidative, inflammatory, and lipid dysregulation suppress hair growth pathways and suggesting new therapeutic targets such as DP2 antagonists and microbiome modulators.
June 2026 in “Russian Journal of Skin and Venereal Diseases” This study evaluated salmon-derived exosomes combined with microneedling as a treatment for androgenetic alopecia, reporting significant improvements in hair density, follicular health, and scalp microenvironment, with no serious adverse events observed in the 20 patients after 12 weeks.
April 2026 in “Research Square” 
April 2026 in “Dermatology and Therapy” This Delphi consensus study provides expert insights into hair aging, aims to enhance diagnostic precision and management of age-related hair changes, and identifies possible new therapeutic targets.
February 2026 in “Scientific Messenger of LNU of Veterinary Medicine and Biotechnology” This review discusses the diagnosis and treatment of dermatophytosis in cats, highlighting the susceptibility of Persian and young cats and the use of antifungal agents and new therapies.
February 2026 in “Frontiers in Public Health” This review discusses the potential impact of lifestyle factors on the progression of androgenetic alopecia and reports no new clinical findings; the authors emphasize the need for more comprehensive studies.
November 2025 in “Journal of Investigative Dermatology” This study identified nine pathogenic variants in the PADI3 gene and variants in the S100A3 and TCHH genes in patients with central centrifugal cicatricial alopecia, suggesting a broader genetic basis for the disease and potential targets for genetic testing and therapies.
November 2025 in “The Journal of Dermatology” This review summarizes recent pathological discoveries related to chemical leukoderma and chemical-induced vitiligo, especially focusing on rhododendrol, a chemical responsible for a significant outbreak affecting around 20,000 individuals in Japan and Asia.
November 2025 in “PubMed” This study identified nine pathogenic variants in the PADI3 gene, and variants in the S100A3 and TCHH genes, which may disrupt protein function and contribute to central centrifugal cicatricial alopecia.
January 2025 in “Frontiers in Medicine” This study reviews the role of hair follicles in the development, symptoms, and treatment options for vitiligo and alopecia areata, aiming to enhance understanding of their involvement in these autoimmune conditions and explore potential therapies.