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This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.

This article explains the preparation methods and applications for various vesicle and particle systems used in transdermal drug delivery, highlighting their effectiveness and potential for further development in this field.

In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.

This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.

This study found that smaller curcumin nanocrystals (60 nm) enhanced transdermal and transfollicular penetration more effectively than larger sizes, influenced by particle size.

This review examines new formulations for delivering 5-α-reductase inhibitors to improve targeted drug delivery in androgenetic alopecia, but reports no new clinical results.

This review highlighted recent advances in nanocarrier-based topical delivery systems for skincare, emphasizing their potential to enhance ingredient stability, penetration, and targeted release while addressing specific pathophysiological skin concerns.

This review discusses the mechanisms and storage of particles in hair follicles and presents no new experimental results, highlighting the need for further research in their safe application in dermatology and cosmetics.

In this study, researchers introduced calcium carbonate-based carriers for transdermal drug delivery, observing efficient transport of substances and systemic absorption in rats, suggesting potential applications in regenerative medicine and dermatology beyond conventional topical treatments.

This review discusses the development of bioactive inorganic particles-based biomaterials for skin tissue engineering and reports no new results; the authors highlight potential future directions for these materials in wound management.

This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.

This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.

This article discusses the foundational concepts of nanotechnology and its contributions to dermatology and medicine, but does not present new research findings.

This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.

This case report describes the characteristic clinicopathological features of trichodysplasia spinulosa in two boys with acute lymphocytic leukemia, highlighting its resolution as immune function normalizes.

This study found that using a protease-triggered release system enabled effective delivery of a model drug deep within porcine hair follicles, suggesting a new approach for treating skin conditions.

This study evaluated green tea extract-loaded spanlastic formulations and found that a vesicle builder to edge activator ratio of 8:2 produced optimal characteristics, including a particle size of 419.70 nm, an entrapment efficiency of 60.85%, and a drug loading of 11.07%.

This review covers follicle-targeting drug delivery systems, exploring their potential for improving localized and systemic therapies, and highlights the need for further research into follicle penetration mechanisms.

In this study, the degradation of HHK scaffold particles was linked to the activation and proliferation of satellite cells, which may contribute to new muscle fiber formation.

This study reports the development of a natural hair-coloring system using size-controlled ink particles from cuttlefish ink combined with chitosan, achieving darker and more uniform black coloration on hair than existing plant-based natural colorants, without the need for metallic mordants.

This review explores how nanoparticles enhance cosmeceutical formulations, analyzing their roles in transporting active ingredients, and highlights the progress and challenges in using nanotechnology for beauty and health products.

The researchers reported that their novel formulation of pterostilbene-loaded ethoniosomes with folic acid coating effectively targeted lung cancer cells in vitro and demonstrated promising results in animal models, indicating potential for future targeted chemotherapy applications.

This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.

The study found that cyproterone acetate-loaded nanostructured lipid carriers, particularly those with a 300 nm diameter, improved skin penetration and targeted hair follicles more effectively than free cyproterone acetate.

In this study, curcumin was successfully encapsulated in ethyl cellulose and its blend with methyl cellulose, enhancing its skin penetration efficacy through o/w and w/o lotions compared to water suspensions.

This study reported that using a Nanostructured Lipid Carrier with a combination of beeswax and oleum cacao improved the characteristics of candlenut oil and enhanced hair growth activity in rats.

The flutamide-loaded hydrogel is a promising, skin-friendly treatment for acne and hair loss, potentially requiring less frequent application.

This study found that curcumin spanlastics demonstrated greater antimicrobial, antioxidant, and anticancer activities in the MCF-7 breast cancer cell line compared to curcumin alone or curcumin nanocrystals, also affecting several cancer-related protein markers and showing enhanced solubility and activity.

In this study, curcumin was efficiently loaded into PS–PAA nanoparticles at the formation stage, showing even distribution at low concentrations and good biocompatibility with human skin fibroblasts.

This study found that an aqueous extract of Phyllanthus emblica, primarily containing gallic acid, can activate hair growth gene expression and is effectively delivered to hair follicles using transfersomes.