Characterization of Spanlastic System Loaded Green Tea Extract as Antioxidant for Skin

The study investigated the use of a spanlastic system to enhance the delivery of green tea extract, which is rich in polyphenols but limited by its hydrophilicity and instability. By testing different weight ratios of vesicle builder (Span 60) and edge activator (Tween® 60), the researchers found that a ratio of 8:2 was optimal. This formulation achieved an entrapment efficiency of 60.85%, drug loading of 11.07%, particle size of 419.70 nm, and a polydispersity index of 0.26. The spanlastic system was a greenish liquid with a zeta potential of 28.53 mV and viscosity of 14.65 cP, indicating its potential as an effective delivery system for green tea extract in skincare applications.