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    Glossary oncogene

    gene that can cause cancer when mutated or overexpressed

    An oncogene is a type of gene that, when mutated or expressed at high levels, can transform a normal cell into a cancerous one. In simpler terms, it's like a switch that, when turned on incorrectly, can lead to uncontrolled cell growth and potentially cancer. For professionals, oncogenes are often derived from proto-oncogenes, which are normal genes involved in cell growth and division, but become harmful when altered.

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    Research 30 of 626

    1. Oncogenes and morphogens: intricacies of targeted therapy in cutaneous basal cell carcinoma British Journal of Dermatology · 2017
    2. Molecular mechanisms of viral oncogenesis in humans Nature Reviews Microbiology · 2018 · 141 citations
    3. The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer Experimental Cell Research · 2019 · 9 citations
    4. Iperplasia Collaterale Nella Oncogenesi Sperimentale Del Ratto: Rilievi in corso di trattamento con Vitamina A Tumori Journal · 1961
    5. The HPV16 oncogenes cause aberrant stem cell mobilization Virology · 2013 · 23 citations
    6. Human Papillomavirus E6/E7 Oncogenes Promote Mouse Ear Regeneration by Increasing the Rate of Wound Re-epithelization and Epidermal Growth Journal of Investigative Dermatology · 2008 · 19 citations
    7. Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen. PubMed · 2000 · 10 citations
    8. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed British Journal of Dermatology · 2004 · 110 citations
    9. Type XVII collagen suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis 2017
    10. Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis 2017
    11. Decision letter: Type XVII collagen coordinates proliferation in the interfollicular epidermis 2017
    12. Skin Cancer: Mechanisms and Human Relevance Medical Entomology and Zoology · 1994 · 213 citations
    13. The Tabby (Ta), Tabby-c (Tac), and Tabby-J (TaJ) Mutations, Chromosome X CRC Press eBooks · 2020 · 2 citations
    14. 0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma Journal of Investigative Dermatology · 2025
    15. Transplantation immunology: Solid organ and bone marrow 2010 · 139 citations
    16. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    17. Normal stem cells and cancer stem cells: similar and different Seminars in Cancer Biology · 2010 · 126 citations
    18. Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7 Journal of Microbiology and Biotechnology · 2023 · 1 citations
    19. From Follicle Cell Differentiation and Structure to Chorion Biogenesis in Insects: Cellular Mechanisms, Gene Regulation, Biochemical Composition and Structural Diversity Insects · 2026
    20. Alex de la Iglesia: "Todos somos perversos" Cambio 16 · 2000
    21. The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs) Proteomes · 2023 · 4 citations
    22. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    23. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    24. p63 expression in normal skin and usual cutaneous carcinomas Journal of Cutaneous Pathology · 2002 · 157 citations
    25. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells Cancer Science · 2008 · 145 citations
    26. Merkel cell carcinoma: updates in tumor biology, emerging therapies, and preclinical models Frontiers in Oncology · 2024 · 17 citations
    27. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors Scientific Reports · 2021 · 4 citations
    28. From geroprotective tactics to anti-ageing strategy:ways to eliminate ageing per se Ageing & Longevity · 2023
    29. Development of Heritable Melanoma in Transgenic Mice Journal of Investigative Dermatology · 1998 · 75 citations
    30. Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development Biology Direct · 2016 · 19 citations