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Glossary Notch signaling

cell communication system regulating development and tissue maintenance

Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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research Epidermal Notch signalling: differentiation, cancer and adhesion

253 citations , April 2008 in “Current opinion in cell biology”

This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.

research The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

134 citations , January 2011 in “Development”

This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

research Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

112 citations , January 2013 in “Experimental dermatology”

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

research Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling

84 citations , September 2008 in “Developmental biology”

This study found that cellular retinoic acid-binding proteins and fatty acid-binding proteins are dynamically expressed in skin development and respond differently to retinoic acid, β-catenin, and Notch signaling.

research Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles

70 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations , January 2011 in “PloS one”

In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.

research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.

research Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway

36 citations , April 2016 in “Biochimie”

This study shows that the concentration of epidermal growth factor (EGF) is crucial for determining whether mink hair follicles are promoted or inhibited in vitro, with involvement of the Notch signaling pathway in DP cell proliferation.

research Pleiotropic Role of Notch Signaling in Human Skin Diseases

29 citations , June 2020 in “International Journal of Molecular Sciences”

This review discusses the role of Notch signaling in skin diseases such as Hidradenitis Suppurativa and Psoriasis, but reports no new clinical results.

research Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature

26 citations , December 2017 in “Journal of Investigative Dermatology”

This study found that the acceleration of endothelial to mesenchymal transition due to loss of Notch signaling led to delayed wound healing and increased scarring in skin wounds.

research Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis

18 citations , February 2017 in “Molecular Medicine Reports”

This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.

research Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway

11 citations , April 2020 in “Life sciences”

In this study, pantothenic acid at 20 μg/ml was observed to promote dermal papilla cell proliferation and migration, likely through up-regulation of ID3 and inhibition of Notch signaling.

research Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits

10 citations , October 2021 in “Animal nutrition”

This study found that dietary pyridoxine increased hair follicle density in Rex rabbits by activating PI3K/Akt, Wnt, and Notch signaling pathways, which may promote hair growth and delay telogen onset.

research Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells

6 citations , January 2016 in “Journal of Stem Cell Research & Therapy”

This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.

research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa

2 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that notch1 signaling is severely impaired in hidradenitis suppurativa patients with or without NCSTN or other gamma-secretase gene mutations, highlighting a canonical defect at the lesional tissue level.

research Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination

April 2026 in “Development”

This study found that loss of integrin-β4 or its ligand, laminin-α3β3ɣ2, in keratinocytes increases differentiation via delamination, and demonstrated a role for hemidesmosomes in epidermal differentiation through both mitotic and non-mitotic mechanisms, influenced by Notch signaling.

research Notch Signaling in Hair Follicle Development

September 2017 in “Asian Journal of Beauty and Cosmetology”

This review discusses recent evidence on the Notch signaling pathway's role in regulating hair follicle development and stem cell differentiation, but provides no new research findings.

research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways

May 2026 in “Scientific Reports”

In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.

research Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts

June 2025 in “Food Science & Nutrition”

This study found that peimine treatment significantly improved wound healing and tissue regeneration in mice by enhancing wound closure, granulation tissue formation, and epidermal thickness, with effects linked to activation of the Notch1 signaling pathway.

research Role of Notch signaling in cell fate determination of dental epithelial stem/progenitor cells

January 2017 in “Zurich Open Repository and Archive (University of Zurich)”

This study presents a new, effective method for delivering dental epithelial stem cells to the jaw, aiming to advance therapies for enamel defects and regeneration.

research Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds

74 citations , April 2024 in “Cell Communication and Signaling”

This review highlights the role of the Wnt/β-catenin signaling pathway in wound healing, particularly in diabetic ulcers, discussing its interactions with other pathways and potential therapeutic strategies targeting this pathway, such as photobiomodulation.

research Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

32 citations , April 2020 in “PLoS Biology”

This study found that Rab5c is crucial for proper HSPC development in zebrafish embryos by regulating Notch and AKT signaling through endocytic trafficking, with both deficiency and overactivation leading to production defects.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations , November 2017 in “Journal of developmental biology”

This review discusses the role of Hedgehog signaling in epidermal and hair follicle development and its involvement in basal cell carcinoma, without reporting new empirical findings.

research Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation

67 citations , December 2008 in “Developmental Biology”

This study found that the transcription factors Msx2 and Foxn1 are crucial for maintaining Notch1 expression in the hair follicle matrix, which is necessary for proper hair differentiation.

research Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway

39 citations , July 2021 in “Stem Cell Research & Therapy”

This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.

research Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

34 citations , November 2010 in “Development”

In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.

research The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

16 citations , March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers observed that a noncanonical mechanism involving the γ-secretase-dependent, RBPj-independent Notch intracellular domain improves survival in Msx2-Cre mice by delaying hair follicle destruction and reducing disease severity.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

The study found that over-expressing ornithine decarboxylase in the outer root sheath of the hair follicle in mice increases UVB-induced tumor growth and invasive squamous cell carcinoma compared to inter-follicular epidermal keratinocytes.