research G136 An Unusual Case of Alopecia in a Toddler
A 2-year-old boy with a rare type of lupus causing hair loss improved with oral steroids.
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research Exploring the Role of Stem Cells in Cutaneous Wound Healing
Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
research Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice
Glycerol is essential for skin hydration in mice without sebaceous glands.
research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene
Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.
research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis
Notch signaling is essential for healthy skin and hair follicle maintenance.
research When Whorls Collide: The Development of Hair Patterns in Frizzled 6 Mutant Mice
Hair follicles in mutant mice self-organize into ordered patterns within a week.
research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors
Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
research Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes
Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.
research Skin Tissue Engineering: Potential of Stem Cell Biology and Skin Morphogenesis
Improved understanding of stem cell mechanisms can enhance skin tissue engineering.
research Zinc and Zinc Transporters in Dermatology
Zinc is crucial for skin health and treating various skin disorders.
research Dynamic Evaluation of Pathological Changes in a Mouse Acne Model by Optical Imaging Technology
New imaging techniques can assess and track changes in mouse acne without harm, aiding treatment choices.
research Intermittent Chronic Telogen Effluvium With an Unusual Dermoscopic Finding Following COVID-19
A 17-year-old girl had severe, on-and-off hair loss, likely due to COVID-19. She was treated with Vitamin D3, biotin, and other supplements, and saw some improvement within a month.
research Vitamin D in Trichology: A Comprehensive Review of the Role of Vitamin D and Its Receptor in Hair and Scalp Disorders
Vitamin D and its receptor are important for hair and scalp health and may help treat hair loss.
research Diffuse Alopecia and Thyroid Atrophy in Sheep
Low zinc and selenium levels in sheep are linked to hair loss and thyroid problems.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing HIF-P4H-2 from certain skin cells in mice causes hair loss on the body but not the head.
research Familial Congenital Generalized Hypertrichosis
A girl inherited excessive body hair from her mother and grandmother.
research Piperine Reduces Hair Oiliness by Inhibiting Adipogenesis of Hair Stem Cells
Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.
research Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis Douglasi, Archer 1979) with Emphasis on Reproductive Pathology
Geriatric Julia Creek dunnarts often suffer from reproductive and skin diseases, impacting conservation efforts.
research Advancing Skin Model Development: A Focus on a Self-Assembled, Induced Pluripotent Stem Cell-Derived, Xeno-Free Approach
A new ethical skin model using stem cells offers a reliable alternative for dermatological research.
research Erosive Pustular Dermatosis of the Scalp in a Patient With Vitiligo Successfully Treated With Topical Antibiotics
Topical antibiotics successfully treated a rare scalp condition in an elderly man with vitiligo.
research Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development
Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.
research The Wonder Tool Platelet-Rich Plasma in Cosmetic Dermatology, Trichology, and Hair Transplant
PRP therapy is effective for hair regrowth and improving hair quality with minimal side effects.
research Psoriasiform Drug Eruption to Finasteride: Uncommon Side Effect of a Commonly Used Drug
Finasteride can cause rare but serious skin rashes.
research Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes
Human dermal stem cells can become functional skin pigment cells.
research Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis
Overexpressing follistatin in mice delays wound healing and reduces scar size.
research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.
research Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid
The study examined the effects of salicylic acid peeling on hairless mice skin, using concentrations of 7.5%, 15.0%, and 30.0%. The 30.0% concentration led to significant exfoliation, epidermal thinning, and increased basal cell proliferation within 24 hours, without causing degeneration or inflammation. Lower concentrations caused minimal changes. The findings indicated that salicylic acid could safely regenerate the epidermis and papillary dermis by injuring the cornified layer without inflammation, suggesting its potential as a chemical peeling method for individuals at risk of pigmentary disorders and keloids. The macrogol vehicle was less irritating than ethanol, which could be advantageous for sensitive patients.
research New Insights into the Role of Runx1 in Epithelial Stem Cell Biology and Pathology
Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.
research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 In Vivo
The study investigated the impact of ornithine decarboxylase (ODC) overexpression on protein kinase CK2 activity and localization, revealing that elevated polyamine levels led to increased CK2 activity and its translocation from the cytoplasm to the nucleus. Despite a significant increase in CK2 protein levels, only a modest rise in enzyme activity was observed, with nuclear CK2 activity increasing 4-fold. In K6/ODC transgenic mice, high ODC activity in hair follicles resulted in hair loss and follicular cysts, suggesting a link between polyamine metabolism and cancer progression. The findings indicated that polyamines might regulate CK2 by affecting its distribution and activity, potentially contributing to tumor development by altering CK2 activity and disrupting normal signal transduction pathways.
research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth
Special cell particles from macrophages can help hair grow.