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GlossaryNon-coding RNAs

molecules of RNA that regulate gene expression without making proteins

Non-coding RNAs (ncRNAs) are molecules of RNA that do not encode proteins but play crucial roles in regulating gene expression and maintaining cellular functions. They include various types such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which can influence processes like cell growth, differentiation, and response to stress, making them important in both normal biology and disease states.

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A Newly Identified Missense Mutation of the HR Gene Is Associated with a Novel, Unusual Phenotype of Marie Unna Hereditary Hypotrichosis 1 Including Limb Deformities

research A Newly Identified Missense Mutation of the HR Gene Is Associated with a Novel, Unusual Phenotype of Marie Unna Hereditary Hypotrichosis 1 Including Limb Deformities

6 citations, May 2012 in “Archives of Dermatological Research”

A new mutation in the HR gene is linked to a rare form of hair loss with limb deformities.

research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

16 citations, November 2022 in “eLife”

Both gene and non-gene areas of DNA evolved to make some mammals hairless.

research Clinical Impact of Molecular Diagnostics in Endocrinology

2 citations, January 2002 in “Hormone Research in Paediatrics”

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

research Editor's Evaluation: Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

March 2022

Hairlessness in mammals is due to complex genetic changes in both genes and regulatory regions.

research Genome Scan for Signatures of Adaptive Evolution in Wild African Goat (Capra Nubiana)

August 2021

Wild African goats have genetic adaptations for surviving harsh desert conditions.

research Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene

26 citations, November 2010 in “Experimental Dermatology”

Two gene areas linked to male pattern baldness found, more research needed.

research Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice

81 citations, February 2014 in “EMBO molecular medicine”

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

15 citations, July 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

9 citations, March 2022 in “Frontiers in Immunology”

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

research Male Pattern Baldness: Current Treatments, Future Prospects

40 citations, July 2008 in “Drug Discovery Today”

Current treatments for male pattern baldness include minoxidil and finasteride, with new options being developed.

research Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update

87 citations, March 2011 in “Australasian Journal of Dermatology”

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

40 citations, March 2019 in “Nature Communications”

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations, January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

research Genome-Wide Detection and Sequence Conservation Analysis of Long Non-Coding RNA During Hair Follicle Cycle of Yak

September 2020 in “Research Square (Research Square)”

Researchers found that certain RNA sequences play a role in yak hair growth and these sequences are somewhat similar to those in cashmere goats.

research Nanotechnology-Based Techniques for Hair Follicle Regeneration

October 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

research Long And Short Non-Coding RNA And Radiation Response: A Review

41 citations, February 2021 in “Translational research”

Non-coding RNAs could help detect and treat radiation damage.

research Nuclear Topology, Epigenetics, and Keratinocyte Differentiation

2 citations, August 2013 in “Journal of Investigative Dermatology”

Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.

research Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome

9 citations, May 2021 in “Frontiers in Cell and Developmental Biology”

DNA methylation changes in women with PCOS could be used as disease markers and suggest new treatment targets.

research Improving Human Forensics Through Advances in Genetics, Genomics, and Molecular Biology

383 citations, February 2011 in “Nature Reviews Genetics”

DNA profiling in forensics has improved, but predicting physical traits and ancestry from DNA has limitations and requires ethical consideration.

research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations, June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

research LncRNAs in Secondary Hair Follicle of Cashmere Goat: Identification, Expression, and Their Regulatory Network in Wnt Signaling Pathway

25 citations, August 2017 in “Animal Biotechnology”

Researchers found that certain RNA molecules might play a role in the growth of Cashmere goat hair.

research Abstracts From The 55th European Society Of Human Genetics Conference: E-Posters

1 citations, May 2023 in “European Journal of Human Genetics”

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.