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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

The document concludes that the androgen receptor's structure and function are complex, affecting how it regulates genes and is involved in diseases like prostate cancer.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Sex steroids affect the MafB gene differently in male and female hamsters.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

ΔNp63α helps control a protein that stops cancer cells from spreading.

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Applying a special compound can promote hair growth without harmful side effects.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

Testosterone may slow down wound healing and increase inflammation.

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

New treatments for acne scars are safer and more effective because we understand the causes better.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

LED light therapy may help hair growth by activating certain cell pathways.

Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Mutations in certain receptors can cause diseases and offer new treatment options.

Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.