Genetic Analysis of Androgen Receptors in Development and Disease
January 1999
in “
Advances in pharmacology
”
TLDR The document concludes that the androgen receptor's structure and function are complex, affecting how it regulates genes and is involved in diseases like prostate cancer.
The document discussed the role of androgen receptors in mediating the actions of androgens, such as testosterone and 5α-dihydrotestosterone, through ligand-dependent transcription. It highlighted the different transactivation domains (AF1, AF2, and AF5) and their ligand dependencies, emphasizing the functional interactions between the NH2-terminal and COOH-terminal domains. The chapter also covered post-translational modifications like phosphorylation and their impact on receptor function, androgen-regulated gene expression, and the implications of androgen receptor mutations in prostate cancer.
