Dimorphic Regulation of the MafB Gene by Sex Steroids in Hamsters (Mesocricetus Auratus)

March 2024 in “ Research Square (Research Square) ”

Luis Ramos

sex steroids MafB gene macrophage differentiation Harderian gland gonadectomy dihydrotestosterone estrous cycle ovaries adrenals insulin glucose secretion sex hormones DHT

TLDR Sex steroids affect the MafB gene differently in male and female hamsters.

This study on hamsters (Mesocricetus auratus) explored how sex steroids regulate the MafB gene, which is crucial for macrophage differentiation. It found that MafB expression is highest in the pancreas and varies between sexes, with males showing higher levels in the Harderian gland (HG) than females. Gonadectomy in males increased MafB mRNA in the HG, normalized by dihydrotestosterone (DHT). The estrous cycle affected MafB expression in the ovaries but not the adrenals. The study, involving 35 adult hamsters, suggests sex steroids significantly influence MafB expression, impacting insulin and glucose secretion in the pancreas and macrophage activity in the HG.

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Dimorphic Regulation of the MafB Gene by Sex Steroids in Hamsters (Mesocricetus Auratus)

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