Dimorphic Regulation of the MafB Gene by Sex Steroids in Hamsters (Mesocricetus Auratus)

March 2024 in “ Research Square (Research Square) ”

Luis Ramos

sex steroids MafB gene macrophage differentiation Harderian gland gonadectomy dihydrotestosterone estrous cycle ovaries adrenals insulin glucose secretion sex hormones DHT

TLDR Sex steroids affect the MafB gene differently in male and female hamsters.

This study on hamsters (Mesocricetus auratus) explored how sex steroids regulate the MafB gene, which is crucial for macrophage differentiation. It found that MafB expression is highest in the pancreas and varies between sexes, with males showing higher levels in the Harderian gland (HG) than females. Gonadectomy in males increased MafB mRNA in the HG, normalized by dihydrotestosterone (DHT). The estrous cycle affected MafB expression in the ovaries but not the adrenals. The study, involving 35 adult hamsters, suggests sex steroids significantly influence MafB expression, impacting insulin and glucose secretion in the pancreas and macrophage activity in the HG.

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community AGA responded to steroid shots? Biopsy wrong? Please help!

in Female 2 upvotes 6 months ago

A woman with AGA is using spironolactone, dutasteride, finasteride, oral minoxidil, bicalutamide, and anti-androgenic birth control but still experiences worsening hair loss. Steroid shots temporarily stop her hair shedding, leading her to question her biopsy results.

community I find it funny a bunch of us on here are on drugs for hairloss and maintain clean/healthy lives and then there’s these mf’s in the 90’s juiced to the gills with steroids and have better hair than all of us lol

in Satire 353 upvotes 1 year ago

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community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 1 year ago

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community 15 years of finasteride/minoxidil

in Update 194 upvotes 6 months ago

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community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

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