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    Glossary Neurosteroids

    steroids produced in the brain that affect neuron function

    Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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    Research 30 of 439

    1. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    2. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    3. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    4. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004 · 180 citations
    5. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    6. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    7. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep Neuroscience · 2007 · 100 citations
    8. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010 · 97 citations
    9. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    10. The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches Pharmacology & Therapeutics · 2004 · 83 citations
    11. Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation Journal of Neuroscience · 2011 · 82 citations
    12. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations
    13. Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy Experimental Neurology · 2006 · 81 citations
    14. Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice Pharmacology Biochemistry and Behavior · 2008 · 66 citations
    15. Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on fetal guinea pig brain development. Journal of Endocrinology · 2010 · 63 citations
    16. Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period Epilepsia · 2009 · 62 citations
    17. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018 · 61 citations
    18. Studies on Neurosteroids XXV. Influence of a 5.ALPHA.-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008 · 61 citations
    19. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model Investigative Ophthalmology & Visual Science · 2014 · 31 citations
    20. Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy Annals of Neurology · 2003 · 30 citations
    21. Role of neurosteroids in the anticonvulsant activity of midazolam British Journal of Pharmacology · 2011 · 28 citations
    22. The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation Neuropsychopharmacology · 2017 · 27 citations
    23. Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration Neuroscience · 2008 · 27 citations
    24. Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress Schizophrenia Research · 2015 · 24 citations
    25. Effect of Neurosteroid Withdrawal on Spontaneous Recurrent Seizures in a Rat Model of Catamenial Epilepsy The FASEB Journal · 2007 · 24 citations
    26. Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids Behavioural Brain Research · 2012 · 24 citations
    27. Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids Cerebral cortex · 2019 · 22 citations
    28. The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice Brain Research · 2008 · 21 citations
    29. Neurosteroid-sensitive δ-GABA<sub>A</sub>receptors: A role in epileptogenesis? Epilepsia · 2017 · 20 citations
    30. Neurosteroid influence on affective tone Neuroscience & Biobehavioral Reviews · 2023 · 19 citations