Role of Neurosteroid Allopregnanolone on Age-Related Differences in Exercise-Induced Hypoalgesia in Rats

November 2018 in “ Journal of pharmacological sciences ”

Bun Aoyama, Takashi Kawano, Hisato Iwata, Atsushi Nishigaki, Daiki Yamanaka, Hiroki Tateiwa, Marie Shigematsu-Locatelli, Satoru Eguchi, Fabricio M. Locatelli, Masataka Yokoyama

allopregnanolone exercise-induced hypoalgesia EIH finasteride naloxone opioid-receptor antagonist neurosteroid ALLO Propecia

TLDR Mild exercise reduces pain in older rats through a brain chemical, while intense exercise reduces pain in all rats through a different pain-blocking process.

The study investigated the effects of exercise intensity on exercise-induced hypoalgesia (EIH) and the role of the neurosteroid allopregnanolone (ALLO) in adult and aged rats. Rats were divided into non-exercise control, Low-exercise (40% maximum oxygen intake), and High-exercise (80% maximum oxygen intake) groups. Low-intensity exercise induced a significant EIH response in aged rats, which was inhibited by the ALLO synthesis inhibitor finasteride, suggesting ALLO's involvement in EIH for aged rats. High-intensity exercise induced EIH in both adult and aged rats, with adults showing a more effective response. The opioid-receptor antagonist naloxone reduced the EIH after high-intensity exercise in both age groups, indicating opioid involvement in EIH at this intensity. The study concluded that mild-intensity exercise can effectively induce EIH in aged animals through increased brain ALLO levels.

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Role of Neurosteroid Allopregnanolone on Age-Related Differences in Exercise-Induced Hypoalgesia in Rats

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