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GlossaryNaloxone

medication that reverses opioid overdoses by blocking opioid receptors

Naloxone, also known by the brand name Narcan, is a medication used to rapidly reverse opioid overdoses. It works by binding to opioid receptors in the brain, displacing the opioid molecules, and blocking their effects, which can quickly restore normal breathing in a person whose breathing has slowed or stopped due to opioid use.

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research The Treatment of Opioid Addiction Leading to Secondary Adrenal Insufficiency

November 2022 in “Journal of the Endocrine Society”

Long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency.

research Expression of Mu-Opiate Receptor in Human Epidermis and Keratinocytes

111 citations, August 1998 in “Journal of Investigative Dermatology”

μ-opiate receptors in skin cells may affect skin health and healing.

research Combined Drug Triads for Synergistic Neuroprotection in Retinal Degeneration

6 citations, April 2022 in “Biomedicine & pharmacotherapy”

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

research Role of Neurosteroid Allopregnanolone on Age-Related Differences in Exercise-Induced Hypoalgesia in Rats

4 citations, November 2018 in “Journal of pharmacological sciences”

Mild exercise reduces pain in older rats through a brain chemical, while intense exercise reduces pain in all rats through a different pain-blocking process.

research Reply

2 citations, December 1997 in “Journal of The American Academy of Dermatology”

The document concludes that doctors should monitor children's brain development when treating hemangiomas with interferon alfa and consider stopping the treatment if problems arise, while also exploring drugs that might counteract side effects.

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