Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats

    July 2020 in “ Behavioural Brain Research ”
    Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès
    Studysummary This study found that neonatal administration of finasteride affected adult learning and memory in rats, enhancing object recognition but impairing aversive learning, with no effect on anxiety-like behavior.
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    Research cited in this study 11

    1. Early Post-Natal Neuroactive Steroid Manipulation Modulates Ondansetron Effects on Initial Periods of Alcohol Consumption in Rats Physiology & behavior · 2018
    2. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018
    3. Effects of Neonatal and Adolescent Neuroactive Steroid Manipulation on Locomotor Activity Induced by Ethanol in Male Wistar Rats Behavioural brain research · 2017
    4. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    5. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    6. Alteration of Neonatal Allopregnanolone Levels Affects Exploration, Anxiety, Aversive Learning, and Adult Behavioral Response to Intrahippocampal Neurosteroids Behavioural Brain Research · 2012
    7. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    8. Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration Neuroscience · 2008
    9. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    10. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    11. Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences Pharmacology, Biochemistry and Behavior · 2004